Document Detail

Secondary preeclampsia in rats with nephrotic syndrome -- experimental model.
MedLine Citation:
PMID:  15749263     Owner:  NLM     Status:  MEDLINE    
The purpose of the study was to investigate the influence that pregnancy has on the progression of primary nephrotic syndrome (NS). We investigated in pregnant rats the clinical characteristics of NS, including urinary protein concentration, serum albumin, cholesterol, triglycerides, urea, creatinine and electrolytes (potassium, sodium, calcium). Proteinuria and edema increasing during pregnancy, hyponatremia, and also exudates to body cavities were signs of secondary preeclampsia. Hypertension appeared in the second half of pregnancy (from the 10th day) and increased during the perinatal period. All signs of preeclampsia disappeared after puerperium, leaving only the signs of NS existing before pregnancy. Primary, idiopathic gestosis occurs only in humans; therefore, research on that type of gestosis should be confirmed clinically.
Agnieszka Pedrycz; Marcin Wieczorski; Krystyna Czerny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  19     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2005 Mar-Apr
Date Detail:
Created Date:  2005-03-07     Completed Date:  2005-07-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-500     Citation Subset:  IM    
Department of Histology and Embryology, Laboratory of Experimental Cytology, Medical University of Lublin, Leonarda Street 5/34, 20-625 Lublin, Poland.
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MeSH Terms
Animals, Newborn
Birth Weight
Disease Models, Animal
Doxorubicin / toxicity
Litter Size
Nephrotic Syndrome / chemically induced,  complications*,  physiopathology
Pre-Eclampsia / etiology*,  physiopathology
Pregnancy Outcome
Rats, Wistar
Reg. No./Substance:

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