| Secondary necrosis: the natural outcome of the complete apoptotic program. | |
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MedLine Citation:
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PMID: 20974143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The predominant definition of apoptosis considers that the elimination of the apoptosing cell is by heterolytic degradation following phagocytosis by an assisting scavenger (efferocytosis). However, an alternative and largely underestimated outcome of apoptosis is secondary necrosis, an autolytic process of cell disintegration with release of cell components that occurs when there is no intervention of scavengers and the full apoptotic program is completed. Secondary necrosis is the typical outcome of apoptosis in unicellular eukaryotes but, importantly, it may also occur in multicellular animals and has been implicated in the genesis of important human pathologies. Secondary necrosis is a mode of cell elimination with specific molecular and morphological features and should be considered the natural outcome of the complete apoptotic program. |
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Authors:
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Manuel T Silva |
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9566123 - Inflammation and apoptosis. 11758823 - Molecular steps of death receptor and mitochondrial pathways of apoptosis. 16101473 - The immune system in space, including earth-based benefits of space-based research. |
Publication Detail:
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Type: Journal Article; Review Date: 2010-10-26 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4491-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Instituto de Biologia Molecular e Celular, University of Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. mtsilva@ibmc.up.pt |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Eukaryotic Cells / pathology Humans Medicine Necrosis / pathology* Phagocytosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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