Document Detail


Secondary myelodysplastic syndrome after hydroxychloroquine therapy.
MedLine Citation:
PMID:  17205285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary myelodysplastic syndromes (MDS) occur in the absence of exposure to ionizing radiation, chemotherapeutic agents or myelotoxic drugs, whereas secondary MDS occurs in the presence of such exposure. We encountered 4 patients among 217 patients on hydroxychloroquine for rheumatological conditions in 2005 diagnosed with MDS. Two patients were male and two were female; the median age was 69.75 years, (range 65-76). The dose of hydroxychloroquine for all patients was 400 mg daily with median treatment duration of 10.5 years and a range of 6-16. All patients had bone marrow biopsy confirmation of the diagnosis of MDS. The incidence of MDS in a group older than 70 years ranges from 15 to 50/100,000 persons per year. The diagnosis of 4 cases of MDS among 217 patients in 1 year is approximately 123-137-fold higher than the risk of MDS in the general population aged more than 70 years (P < 0.001) and suggests that long-term treatment with hydroxychloroquine is associated with an increased risk of developing secondary MDS.
Authors:
Alaa A Muslimani; Timothy P Spiro; Asif A Chaudhry; Hamed A Daw
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Publication Detail:
Type:  Letter     Date:  2007-01-05
Journal Detail:
Title:  Annals of hematology     Volume:  86     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Hydroxychloroquine / adverse effects*
Male
Myelodysplastic Syndromes / chemically induced*
Retrospective Studies
Rheumatic Diseases / drug therapy*
Chemical
Reg. No./Substance:
118-42-3/Hydroxychloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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