Document Detail

Secondary metabolites with new medicinal functions from marine organisms.
MedLine Citation:
PMID:  22361187     Owner:  NLM     Status:  In-Data-Review    
We have focused on the identification of natural key compounds that possess biologically and medicinally intriguing functions. Some of bioactive naturally occurring compounds isolated from marine organisms were found to possess unique biological activities. Halichlorine from the marine sponge Halichondria okadai was shown to inhibit the activity of nuclear factor-κB in endothelial cells and block L-type Ca(2+) channels. Thus, it may have therapeutic potentials for diseases such as atherosclerosis and hypertension.
Osamu Ohno; Kiyotake Suenaga; Daisuke Uemura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in food and nutrition research     Volume:  65     ISSN:  1043-4526     ISO Abbreviation:  Adv. Food Nutr. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9001271     Medline TA:  Adv Food Nutr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
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