Document Detail


Secondary metabolites by chemical screening: II. Amycins A and B two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin.
MedLine Citation:
PMID:  2257019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two novel natural niphimycin analogs, amycins A (5) and B (3) were isolated from the culture broth of the Streptomyces sp. DSM 3816 by chemical screening methods. In addition this strain produces the antibiotics niphimycin (4), elaiophylin (2) and nigericin (1). Fermentation, isolation, structure elucidation and biological activity of the amycins are described.
Authors:
S Grabley; P Hammann; W Raether; J Wink; A Zeeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  43     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  639-47     Citation Subset:  IM    
Affiliation:
Hoechst Aktiengesellschaft, Frankfurt a.M., FRG.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / analysis,  biosynthesis*,  isolation & purification,  pharmacology
Antifungal Agents / analysis,  biosynthesis*,  isolation & purification,  pharmacology
Chromatography, Thin Layer
Fermentation
Fungi / drug effects
Gram-Positive Bacteria / drug effects
Guanidines / analysis,  isolation & purification,  metabolism,  pharmacology
Macrolides*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microscopy, Electron, Scanning
Molecular Structure
Nigericin / biosynthesis
Streptomyces / classification,  metabolism*,  ultrastructure
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Guanidines; 0/Macrolides; 116296-63-0/amycin A; 12676-71-0/niphimycin; 129313-99-1/amycin B; 28380-24-7/Nigericin; 37318-06-2/elaiophylin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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