Document Detail

Secondary hyperparathyroidism in osteomalacia.
MedLine Citation:
PMID:  5411449     Owner:  NLM     Status:  MEDLINE    
Twenty-one patients with histologically proved osteomalacia from various causes were investigated for biochemical and radiological evidence of osteomalacia and secondary hyperparathyroidism. Among the 15 who maintained a normal serum calcium, seven had a raised phosphate excretion index, seven had a raised serum alkaline phosphatase, and six had phalangeal erosions. On the other hand, six patients had a subnormal serum calcium; of these, none showed a raised phosphate excretion index, one had a raised serum alkaline phosphatase, and one had erosions. The phosphate excretion index and the alkaline phosphatase were strongly correlated (r = +0.84). It is concluded that this absence of manifest secondary hyperparathyroidism in some patients with osteomalacia is due to failure of an increase in the release of parathyroid hormone. Measurement of phosphaturia does not appear to be a useful means of detecting osteomalacia. Subsequently, the 24-hour (stable) strontium space measurement was found to be the most sensitive single biochemical screening test for osteomalacia.
N C Thalassinos; S Wicht; G F Joplin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1970 Jan 
Date Detail:
Created Date:  1970-03-05     Completed Date:  1970-03-05     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  AIM; IM    
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MeSH Terms
Alkaline Phosphatase / blood
Calcium / blood
Hand / radiography
Hyperparathyroidism, Secondary / complications*
Middle Aged
Osteomalacia / blood,  complications*,  diagnosis,  metabolism
Parathyroid Hormone / secretion
Phosphates / metabolism,  urine
Strontium / diagnostic use
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 7440-24-6/Strontium; 7440-70-2/Calcium; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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