| Secondary hyperparathyroidism in osteomalacia. | |
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MedLine Citation:
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PMID: 5411449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-one patients with histologically proved osteomalacia from various causes were investigated for biochemical and radiological evidence of osteomalacia and secondary hyperparathyroidism. Among the 15 who maintained a normal serum calcium, seven had a raised phosphate excretion index, seven had a raised serum alkaline phosphatase, and six had phalangeal erosions. On the other hand, six patients had a subnormal serum calcium; of these, none showed a raised phosphate excretion index, one had a raised serum alkaline phosphatase, and one had erosions. The phosphate excretion index and the alkaline phosphatase were strongly correlated (r = +0.84). It is concluded that this absence of manifest secondary hyperparathyroidism in some patients with osteomalacia is due to failure of an increase in the release of parathyroid hormone. Measurement of phosphaturia does not appear to be a useful means of detecting osteomalacia. Subsequently, the 24-hour (stable) strontium space measurement was found to be the most sensitive single biochemical screening test for osteomalacia. |
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Authors:
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N C Thalassinos; S Wicht; G F Joplin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British medical journal Volume: 1 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1970 Jan |
Date Detail:
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Created Date: 1970-03-05 Completed Date: 1970-03-05 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 76-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Alkaline Phosphatase / blood Calcium / blood Female Hand / radiography Humans Hyperparathyroidism, Secondary / complications* Male Middle Aged Osteomalacia / blood, complications*, diagnosis, metabolism Parathyroid Hormone / secretion Phosphates / metabolism, urine Strontium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 0/Phosphates; 7440-24-6/Strontium; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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