| Secondary hyperparathyroidism and cardiac hypertrophy in hemodialysis patients. | |
| | |
MedLine Citation:
|
PMID: 2963169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Echocardiographic assessment of left ventricular function was performed in 66, stable hemodialysis patients and 50 normal controls matched for sex, age and arterial blood pressure. On the basis of bone histology, hemodialysis patients were classified into two groups: (1) patients with normal bone resorption; and (2) patients with active secondary hyperparathyroidism characterized by an increased bone resorption. Left ventricular function of these two subgroups were compared together as well as with the echocardiographic characteristics of normal controls. In comparison with normal controls, hemodialysis patients with normal bone resorption had an increased left ventricular volume (P less than 0.001) and left ventricular mass (P less than 0.001) with a similar left ventricular mass-to-volume ratio. Their systolic arterial pressure--mass-to-volume ratio correlation was similar to that of normal controls, indicating an adequate myocardial hypertrophy. Patients with increased bone resorption had high parathormone and alkaline phosphatase levels; though the left ventricular dilation was similar to that of hemodialysis patients with normal bone resorption, the left ventricular mass was lower (P less than 0.001) and was similar to the left ventricular mass of normal controls. In addition, patients with increased bone resorption had a lower mass-to-volume ratio (P less than 0.001) and their systolic arterial pressure--mass-to-volume ratio correlation exhibited a significant downward shift (P less than 0.001), suggesting an inadequate myocardial hypertrophy. Patients with increased bone resorption and secondary hyperparathyroidism had an increased heart rate, a higher systolic arterial pressure and end-systolic stress. Furthermore, they had an increased velocity of fiber shortening (P less than 0.01) and shorter left ventricular ejection time (P less than 0.001). In summary, present data suggest the possibility that parathormone may exert myocardial effects in hemodialysis patients. |
| | |
Authors:
|
G M London; M C De Vernejoul; F Fabiani; S J Marchais; A P Guerin; F Metivier; A M London; F Llach |
Related Documents
:
|
12122119 - The mekk1-jnk pathway plays a protective role in pressure overload but does not mediate... 3944349 - Assessment of pericardial constraint: the relation between right ventricular filling pr... 17174589 - A two phase harmonic model for left ventricular function. 893679 - Evidence for cardiomyopathy in familial diabetes mellitus. 954069 - Right ventricular mass estimation by angioechocardiography. 10619589 - Reduction in arterial distensibility in hypertensive patients as evaluated by ambulator... 8205519 - The center of pressure index in the evaluation of foot orthoses in shoes. 20729159 - Central blood pressure measurements-an opportunity for efficacy and safety in drug deve... 9149589 - Comparison of pressure support ventilation and assist-control ventilation in the treatm... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Kidney international Volume: 32 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 1987 Dec |
Date Detail:
|
Created Date: 1988-03-09 Completed Date: 1988-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 900-7 Citation Subset: IM |
Affiliation:
|
Centre Hospitalier F.H. Manhes, Fleury-Mergois, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure Bone Resorption Cardiomegaly / complications*, physiopathology Echocardiography Female Humans Hyperparathyroidism, Secondary / complications*, physiopathology Male Middle Aged Parathyroid Hormone / blood Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
|
0/Parathyroid Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction, characterization, and cell transfer of autoimmune tubulointerstitial nephritis.
Next Document: On the role of additive hormone monotherapy with tamoxifen, medroxyprogesterone acetate and aminoglu...