Document Detail

Secondary hyperbaric oxygen therapy for idiopathic sudden sensorineural hearing loss in the subacute and chronic phases.
MedLine Citation:
PMID:  21073130     Owner:  NLM     Status:  MEDLINE    
This study investigated the efficacy of hyperbaric oxygen therapy (HBOT) as a secondary treatment for patients with idiopathic sudden sensorineural hearing loss (ISSNHL) in the subacute and chronic phases. Forty-eight ISSNHL patients (HBOT group) who had received primary conventional treatment within 4 weeks after onset and underwent HBOT between 4 and 20 weeks post-onset were retrospectively compared with 44 ISSNHL patients (control group) with primary conventional treatment alone. Mean hearing gain was slight, with gains of 5.2 +/- 8.9 dB in the HBOT group and 2.0 +/- 7.6 dB in the control group. However, no significant difference was recognized between the two groups. In the HBOT group, no significant difference was observed in hearing gain among patients with HBOT initial time at 4-7, 8-11, 12-15 or 16-20 weeks after onset. Meanwhile, hearing gain was significantly higher in patients with profound hearing loss than in the other patients. We conclude that the effectiveness of secondary HBOT for ISSNHL patients in either subacute or chronic phase remains unproven, and thus, the decision administer HBOT should be made with caution.
Kazuchika Ohno; Yoshihiro Noguchi; Yoshiyuki Kawashima; Kazuyoshi Yagishita; Ken Kitamura
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of medical and dental sciences     Volume:  57     ISSN:  1342-8810     ISO Abbreviation:  J. Med. Dent. Sci.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9717112     Medline TA:  J Med Dent Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  D; IM    
Department of Otolaryngology, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Acute Disease
Audiometry, Pure-Tone
Chronic Disease
Hearing Loss, Sensorineural / therapy*
Hyperbaric Oxygenation*
Middle Aged
Treatment Failure

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