Document Detail

Secondary effects of antipsychotic treatment in naive or quasi-naive children and adolescents: Design of a follow-up protocol and baseline results.
MedLine Citation:
PMID:  23021294     Owner:  NLM     Status:  Publisher    
INTRODUCTION: The prescribing of anti-psychotic drugs has become a normal clinical practice. METHODS: This article presents a longitudinal, multicentre study of 12 months conducted on 266 children and adolescents who were prescribed a first or second generation antipsychotic drug for the first time, and the baseline results of the study. The follow-up protocol had as its purpose to detect the possible appearance of metabolic, cardiological, and motor changes. RESULTS: When the presence of side effects was evaluated using the UKU (clinical side-effects scale) statistically significant differences were found between naive (patients who had never taken an anti-psychotic drug) and quasi-naive patients (those who have taken anti-psychotic drugs for a period of less than 30 days), with a greater number of the latter showing symptoms of: anxiety/laxity/tiredness (P=.0049), drowsiness/sedation (P<.001), increase in dream duration (P<.001), increase in dreams (P=.0199), emotional indifference (P=.0194), hypokinesia/akinesia (P=.0224), paresthesias (P=.0049), accommodation disorder (P=.0254), increase in salivation (P<.001), polyuria/polydipsia (P=.0076), increase in sweating (P=.0076), increase in sexual desire (P=.0117), decrease in sexual desire (P=.0053), tension headaches (P=.0405). When the presence of extrapyramidal symptoms was assessed using the MPRC-IMS (Maryland Psychiatry Research Center-Involuntary Movements) Scale, it was observed that the quasi-naïve patients had a statistically higher number of dyskinesia (P=.002), Parkinsonism (P=.0004) and akathisia (P=.0437) symptoms compared to the naïve patients. CONCLUSIONS: These results show that, in the childhood-adolescent population, the presence of secondary effects begins to be observed from the first dose of the antipsychotic drug.
Jessica Merchán-Naranjo; Cecilia Tapia; Concha Bailón; Carmen Moreno; Inmaculada Baeza; Rosa Calvo-Escalona; Astrid Morer; Carmen Martínez-Cantarero; Patricia Andrés Nestares; José Ángel Alda; Daniel Muñoz; Celso Arango
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-30
Journal Detail:
Title:  Revista de psiquiatria y salud mental     Volume:  5     ISSN:  1989-4600     ISO Abbreviation:  Rev Psiquiatr Salud Ment     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528851     Medline TA:  Rev Psiquiatr Salud Ment     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  217-228     Citation Subset:  -    
Copyright Information:
Copyright © 2011 SEP y SEPB. Published by Elsevier Espana. All rights reserved.
Sección de Psiquiatría del Niño y el Adolescente, Departamento de Psiquiatría. CIBERSAM, Instituto de Investigación Sanitaria Gregorio Marañón, IISGM. Hospital General Universitario Gregorio Marañón, Madrid, España. Electronic address:
Vernacular Title:
Efectos secundarios del tratamiento antipsicótico en niños y adolescentes naïve o quasi-naïve: diseño de un protocolo de seguimiento y resultados basales.
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