Document Detail


Secondary antibodies as tools to improve tumor to non tumor ratio at radioimmunolocalisation and radioimmunotherapy.
MedLine Citation:
PMID:  8679257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One way of selectively improving the efficiency of radioimmunolocalization and radioimmunotherapy is to eliminate redundant, circulating, non-targeting radiolabeled antibodies after saturation of the target sites. Secondary antibodies of different types have been proposed as clearing agents for such purposes. The conceptually different approaches of the 'secondary antibody' strategy including its advantages and limitations are discussed. This mini-review also presents a model describing the kinetics of the components (the antigen, the primary and secondary antibodies) and approaches required to improve the efficacy of both radioimmunolocalization and radioimmunotherapy.
Authors:
A Ullén; K R Ahlström; S Heitala; B Nilsson; L Arlestig; T Stigbrand
Related Documents :
9263117 - Sepsis and polyspecific intravenous immunoglobulins.
10837727 - Antibodies as delivery systems for diagnostic functions.
11586277 - Antibody-directed therapy: past, present, and future.
20073127 - Bispecific antibodies for cancer therapy: the light at the end of the tunnel?
3316387 - Role of accessory molecules in signal transduction of cytolytic t lymphocyte by anti-t ...
2445597 - Inhibition of hemoglobin accumulation by monoclonal antibodies to the human transferrin...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  35     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1996  
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  281-5     Citation Subset:  IM    
Affiliation:
Department of Immunology, University of Umea, Umea Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Anti-Idiotypic / administration & dosage,  blood
Antibodies, Neoplasm / administration & dosage*,  blood
Antigen-Antibody Reactions
Antigens, Neoplasm / immunology
Humans
Immunoglobulin Fragments / administration & dosage,  blood
Neoplasms / metabolism,  radionuclide imaging*,  radiotherapy*
Radioimmunodetection*
Radioimmunotherapy*
Chemical
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/Immunoglobulin Fragments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Penetration and binding of monoclonal antibody in human osteosarcoma multicell spheroids. Comparison...
Next Document:  Generation of human monoclonal antibodies against ganglioside antigens and their applications in the...