| Secondary antibodies as tools to improve tumor to non tumor ratio at radioimmunolocalisation and radioimmunotherapy. | |
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MedLine Citation:
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PMID: 8679257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One way of selectively improving the efficiency of radioimmunolocalization and radioimmunotherapy is to eliminate redundant, circulating, non-targeting radiolabeled antibodies after saturation of the target sites. Secondary antibodies of different types have been proposed as clearing agents for such purposes. The conceptually different approaches of the 'secondary antibody' strategy including its advantages and limitations are discussed. This mini-review also presents a model describing the kinetics of the components (the antigen, the primary and secondary antibodies) and approaches required to improve the efficacy of both radioimmunolocalization and radioimmunotherapy. |
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Authors:
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A Ullén; K R Ahlström; S Heitala; B Nilsson; L Arlestig; T Stigbrand |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Acta oncologica (Stockholm, Sweden) Volume: 35 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 1996 |
Date Detail:
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Created Date: 1996-08-22 Completed Date: 1996-08-22 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 281-5 Citation Subset: IM |
Affiliation:
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Department of Immunology, University of Umea, Umea Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Anti-Idiotypic / administration & dosage, blood Antibodies, Neoplasm / administration & dosage*, blood Antigen-Antibody Reactions Antigens, Neoplasm / immunology Humans Immunoglobulin Fragments / administration & dosage, blood Neoplasms / metabolism, radionuclide imaging*, radiotherapy* Radioimmunodetection* Radioimmunotherapy* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/Immunoglobulin Fragments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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