Document Detail

Secondary antibodies as tools to improve tumor to non tumor ratio at radioimmunolocalisation and radioimmunotherapy.
MedLine Citation:
PMID:  8679257     Owner:  NLM     Status:  MEDLINE    
One way of selectively improving the efficiency of radioimmunolocalization and radioimmunotherapy is to eliminate redundant, circulating, non-targeting radiolabeled antibodies after saturation of the target sites. Secondary antibodies of different types have been proposed as clearing agents for such purposes. The conceptually different approaches of the 'secondary antibody' strategy including its advantages and limitations are discussed. This mini-review also presents a model describing the kinetics of the components (the antigen, the primary and secondary antibodies) and approaches required to improve the efficacy of both radioimmunolocalization and radioimmunotherapy.
A Ullén; K R Ahlström; S Heitala; B Nilsson; L Arlestig; T Stigbrand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  35     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1996  
Date Detail:
Created Date:  1996-08-22     Completed Date:  1996-08-22     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  281-5     Citation Subset:  IM    
Department of Immunology, University of Umea, Umea Sweden.
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MeSH Terms
Antibodies, Anti-Idiotypic / administration & dosage,  blood
Antibodies, Neoplasm / administration & dosage*,  blood
Antigen-Antibody Reactions
Antigens, Neoplasm / immunology
Immunoglobulin Fragments / administration & dosage,  blood
Neoplasms / metabolism,  radionuclide imaging*,  radiotherapy*
Reg. No./Substance:
0/Antibodies, Anti-Idiotypic; 0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/Immunoglobulin Fragments

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