| Secondary analysis of the use of transdermal nitroglycerin for preterm labor. | |
| | |
MedLine Citation:
|
PMID: 20817132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This secondary analysis of a randomized placebo-controlled trial was to hypothesize on mechanisms for the improved neonatal outcomes with the use of nitroglycerin (GTN) for preterm labor. STUDY DESIGN: Women in the original trial who delivered at term were excluded. A composite of severe neonatal outcomes, gestational age at delivery, and corticosteroid use in addition to Kaplan-Meier survival analysis to assess time from randomization to delivery were examined. RESULTS: A decrease in composite neonatal outcome (relative risk, 0.21; 95% confidence interval, 0.05-0.81; P = .018) with GTN (n = 39) compared with placebo (n = 38) was primarily due to a 23 day prolongation of pregnancy (P = .019) and a trend (P = .04) toward completing a course of corticosteroids in the subgroup randomized prior to 28 weeks' gestation. CONCLUSION: We hypothesize that GTN has a gestational age-dependent reduction in neonatal outcomes as a result of pregnancy prolongation and corticosteroid administration. |
| | |
Authors:
|
Graeme N Smith; Yanfang Guo; Shi Wu Wen; Mark C Walker; |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-29 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
|
Languages: eng Pagination: 565.e1-6 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Obstetrics and Gynecology, Queen's Perinatal Research Unit, Kingston General Hospital, Queen's University, Kingston, ON, Canada. gns@queensu.ca. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Adult Confidence Intervals Delivery, Obstetric / methods Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Gestational Age* Humans Infant, Newborn Maternal Age Nitroglycerin / administration & dosage* Obstetric Labor, Premature / drug therapy*, prevention & control Pregnancy Pregnancy Outcome* Reference Values Term Birth* Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
MCT 41550//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
|
55-63-0/Nitroglycerin |
| Investigator | |
Investigator/Affiliation:
|
Marie-France Delisle / ; Vesna Popovska / ; Shelley Soanes / ; Nestor Demianczuk / ; Elizabeth Penttinen / ; Trevor Cohen / ; Ken Seethram / ; Gwen Schmidt / ; George Carson / ; Sandy Holfeld / ; Jodie Bikalky / ; Barbara Brennan / ; Patti Hudson / ; Kelly Pearce / ; Rory Windrim / ; Mary Ellen Salenieks / ; Maryam Yeganegi / ; Karen Muller / ; Jon Barrett / ; Jennifer Cram / ; Shelly Petruskavich / ; Sheila Welch / ; Peter Maskens / ; Elly Hartwick / ; Graeme N Smith / ; Christine Rafuse / ; Mark Walker / ; Shi-Wu Wen / ; Ruth Rennicks White / ; Tracey Meeker / ; Julie Guimond / ; Michelle Laperriere / ; Joan Crane / ; Donna Hutchens / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age of acquisition effects in vocabulary learning.
Next Document: Fear generalization in humans: Impact of prior non-fearful experiences.