Document Detail


Secondary analysis of the use of transdermal nitroglycerin for preterm labor.
MedLine Citation:
PMID:  20817132     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This secondary analysis of a randomized placebo-controlled trial was to hypothesize on mechanisms for the improved neonatal outcomes with the use of nitroglycerin (GTN) for preterm labor.
STUDY DESIGN: Women in the original trial who delivered at term were excluded. A composite of severe neonatal outcomes, gestational age at delivery, and corticosteroid use in addition to Kaplan-Meier survival analysis to assess time from randomization to delivery were examined.
RESULTS: A decrease in composite neonatal outcome (relative risk, 0.21; 95% confidence interval, 0.05-0.81; P = .018) with GTN (n = 39) compared with placebo (n = 38) was primarily due to a 23 day prolongation of pregnancy (P = .019) and a trend (P = .04) toward completing a course of corticosteroids in the subgroup randomized prior to 28 weeks' gestation.
CONCLUSION: We hypothesize that GTN has a gestational age-dependent reduction in neonatal outcomes as a result of pregnancy prolongation and corticosteroid administration.
Authors:
Graeme N Smith; Yanfang Guo; Shi Wu Wen; Mark C Walker;
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  565.e1-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Queen's Perinatal Research Unit, Kingston General Hospital, Queen's University, Kingston, ON, Canada. gns@queensu.ca.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Confidence Intervals
Delivery, Obstetric / methods
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Follow-Up Studies
Gestational Age*
Humans
Infant, Newborn
Maternal Age
Nitroglycerin / administration & dosage*
Obstetric Labor, Premature / drug therapy*,  prevention & control
Pregnancy
Pregnancy Outcome*
Reference Values
Term Birth*
Treatment Outcome
Young Adult
Grant Support
ID/Acronym/Agency:
MCT 41550//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin
Investigator
Investigator/Affiliation:
Marie-France Delisle / ; Vesna Popovska / ; Shelley Soanes / ; Nestor Demianczuk / ; Elizabeth Penttinen / ; Trevor Cohen / ; Ken Seethram / ; Gwen Schmidt / ; George Carson / ; Sandy Holfeld / ; Jodie Bikalky / ; Barbara Brennan / ; Patti Hudson / ; Kelly Pearce / ; Rory Windrim / ; Mary Ellen Salenieks / ; Maryam Yeganegi / ; Karen Muller / ; Jon Barrett / ; Jennifer Cram / ; Shelly Petruskavich / ; Sheila Welch / ; Peter Maskens / ; Elly Hartwick / ; Graeme N Smith / ; Christine Rafuse / ; Mark Walker / ; Shi-Wu Wen / ; Ruth Rennicks White / ; Tracey Meeker / ; Julie Guimond / ; Michelle Laperriere / ; Joan Crane / ; Donna Hutchens /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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