| Secondary alteration of the transferrin isoelectric focusing pattern in a case of bacterial meningitis. | |
| | |
MedLine Citation:
|
PMID: 17372855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Congenital disorders of glycosylation (CDG) are a group of inherited defects in the synthesis and processing of the linked glycans of glycoproteins and other glycoconjugates. The phenotypic spectrum presents wide variability, and clinical diagnosis is not reliable in most cases. Isoelectric focusing (IEF) of serum transferrin is widely used as a tool to detect CDG. We describe a paediatric patient presenting an altered serum transferrin pattern due to a secondary disorder of glycosylation caused by pneumococcal meningitis (Streptococcus pneumoniae, serotype 19A). During admission, brain CT scan and MRI showed acute ischaemic lesions in brain frontotemporal parenchyma, and enlarged subarachnoidal spaces in the frontal area resembling a chronic injury. This led us to screen for inborn errors of metabolism potentially associated with these findings (homocystinuria, glutaric aciduria, CDG syndromes). Biochemical studies for the screening of these inborn errors of metabolism were normal except for sialotransferrin isoelectric focusing, which showed a type 2 pattern. However, 16 days later, together with the remission of the meningitis process, the sialotransferrin pattern had normalized. The apolipoprotein C-III (an O-glycoprotein) profile was normal in all samples analysed. In conclusion, infectious events should be ruled out in the differential diagnosis of CDG syndromes. Furthermore, our findings highlight the possibility that the type 2 IEF pattern of serum sialotransferrin detected in some patients with neonatal death due to organ failure and septic events might be secondary to the infectious process. |
| | |
Authors:
|
E Quintana; S Gala; A García-Cazorla; R Montero; C Muñoz-Almagro; M A Vilaseca; P Briones; R Artuch |
Related Documents
:
|
9725305 - Lymphoproliferative disorders: ct findings in immunocompromised children. 9662565 - Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease... 19880495 - Long-term outcome of ebv-specific t-cell infusions to prevent or treat ebv-related lymp... 9849695 - Lymphoproliferative disorders following allogeneic bone marrow transplantation: the van... 23679875 - Oral kaposi's sarcoma: a review and update. 10482945 - Inappropriate antidiuretic hormone secretion after high-dose thiotepa. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-15 |
Journal Detail:
|
Title: Journal of inherited metabolic disease Volume: 30 ISSN: 1573-2665 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-20 Completed Date: 2007-04-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 267 Citation Subset: IM |
Affiliation:
|
Institut de Bioquímica Clínica, Hospital Clínic, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbohydrate Metabolism, Inborn Errors
/
diagnosis Diagnosis, Differential Glycosylation Humans Infant Isoelectric Focusing* Male Meningitis, Bacterial / blood*, diagnosis Pneumococcal Infections / blood*, diagnosis Sialoglycoproteins / blood* Transferrin / analogs & derivatives*, metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Sialoglycoproteins; 0/sialotransferrin, human; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Severe infantile type of carnitine palmitoyltransferase II (CPT II) deficiency due to homozygous R50...
Next Document: Effects of duration and amount of lung stretch at biophysical, biochemical, histological, and transc...