Document Detail


Secondary abnormalities of neurotransmitters in infants with neurological disorders.
MedLine Citation:
PMID:  17880642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurotransmitters are essential in young children for differentiation and neuronal growth of the developing nervous system. We aimed to identify possible factors related to secondary neurotransmitter abnormalities in pediatric patients with neurological disorders. We analyzed cerebrospinal fluid (CSF) and biogenic amine metabolites in 56 infants (33 males, 23 females; mean age 5.8mo [SD 4.1mo] range 1d-1y) with neurological disorders whose aetiology was initially unknown. Patients were classified into three clinical phenotypes: epileptic encephalopathy, severe motor impairment, and non-specific manifestations. All patients showed normal results for screening of inborn errors of metabolism. We report clinical, neuroimaging, and follow-up data. Among the patients studied, 10 had low homovanillic acid (HVA) levels and in four patients, 5-hydroxyindoleacetic acid (5-HIAA) was also reduced. Patients with neonatal onset had significantly lower levels of HVA than a comparison group. HVA deficiency was also associated with severe motor impairment and the final diagnosis related to neurodegenerative disorders. 5-HIAA values tended to be decreased in patients with brain cortical atrophy. The possibility of treating patients with L-Dopa and 5-hydroxytryptophan, in order to improve their neurological function and maturation, may be considered.
Authors:
A García-Cazorla; M Serrano; B Pérez-Dueñas; V González; A Ormazábal; M Pineda; E Fernández-Alvarez; J M D Campistol; R M D Artuch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  49     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-11-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  740-4     Citation Subset:  IM    
Affiliation:
Neurology Department, Hospital Sant Joan de Déu, University of Barcelona and Centre for Biomedical Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain. agarcia@hsjdbcn.org
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MeSH Terms
Descriptor/Qualifier:
5-Hydroxytryptophan / cerebrospinal fluid*
Atrophy / pathology
Brain / pathology*
Electroencephalography
Epilepsy* / cerebrospinal fluid,  diagnosis,  etiology
Female
Homovanillic Acid / cerebrospinal fluid*
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Infant
Infant, Newborn
Male
Motor Skills Disorders* / cerebrospinal fluid,  etiology,  physiopathology
Nervous System Diseases* / cerebrospinal fluid,  complications,  diagnosis
Phenotype
Pterins / cerebrospinal fluid*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Pterins; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 56-69-9/5-Hydroxytryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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