Document Detail

Secondary responses to altered acid-base status: the rules of engagement.
MedLine Citation:
PMID:  20431042     Owner:  NLM     Status:  MEDLINE    
Each of the four canonical acid-base disorders expresses as a primary change in carbon dioxide tension or plasma bicarbonate concentration followed by a secondary response in the countervailing variable. Quantified empirically, these secondary responses are directional and proportional to the primary changes, run a variable time course, and tend to minimize the impact on body acidity engendered by the primary changes. Absence of an appropriate secondary response denotes the coexistence of an additional acid-base disorder. Here we address the expected magnitude of the secondary response to each cardinal acid-base disorder in humans and offer caveats for judging the appropriateness of each secondary response.
Horacio J Adrogu?; Nicolaos E Madias
Publication Detail:
Type:  Journal Article     Date:  2010-04-29
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  21     ISSN:  1533-3450     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  920-3     Citation Subset:  IM    
Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid-Base Equilibrium / physiology
Acid-Base Imbalance / metabolism*
Acidosis / metabolism
Acidosis, Respiratory / metabolism
Bicarbonates / blood*
Carbon Dioxide / metabolism*
Hypocapnia / metabolism
Time Factors
Reg. No./Substance:
0/Bicarbonates; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and l...
Next Document:  Randomized Intervention Studies in Human Polycystic Kidney and Liver Disease.