Document Detail


Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa.
MedLine Citation:
PMID:  20658670     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumisoflavone (9) genistein (10), 2'-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6beta-hydroxystigmast-4-en-3-one (20) and 6beta-hydroxystigmasta-4,22-dien-3-one (21), and a mixture of beta-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H(37)R(V) in vitro with MIC values of 16, 35, 30, and < or =2.8 microg/ml, respectively.
Authors:
Li-Wen Chen; Ming-Jen Cheng; Chien-Fang Peng; Ih-Sheng Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry & biodiversity     Volume:  7     ISSN:  1612-1880     ISO Abbreviation:  Chem. Biodivers.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197449     Medline TA:  Chem Biodivers     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1814-21     Citation Subset:  IM    
Affiliation:
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R.O.C.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry*,  isolation & purification,  pharmacology*
Coumarins / chemistry,  isolation & purification,  pharmacology
Ficus / chemistry*
Flavonoids / chemistry,  isolation & purification,  pharmacology
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Plant Extracts / chemistry*,  isolation & purification,  pharmacology*
Plant Roots / chemistry*
Steroids / chemistry,  isolation & purification,  pharmacology
Triterpenes / chemistry,  isolation & purification,  pharmacology
Tuberculosis / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Coumarins; 0/Flavonoids; 0/Plant Extracts; 0/Steroids; 0/Triterpenes

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