| Secondary metabolites and antimycobacterial activities from the roots of Ficus nervosa. | |
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MedLine Citation:
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PMID: 20658670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bioassay-guided fractionation of the active AcOEt-soluble layer led to the isolation of two new pyranocoumarins, 3-hydroxyxanthyletin (1) and 3-methoxyxanthyletin (2), along with 22 known compounds including four simple coumarins, i.e., xanthyletin (3), umbelliferone (4), scopoletin (5), and (+)-(S)-marmesin (6); nine flavonoids, i.e., carpachromene (7), parvisoflavone B (8), alpinumisoflavone (9) genistein (10), 2'-hydroxygenistein (11), prunetin (12), cajanin (13), apigenin (14), and (2S)-naringenin (15); three benzenoids, i.e., 4-hydroxybenzaldehyde (16), vanillin (17), and (S)-lasiodiplodin (18); five steroids, i.e., ergosterol peroxide (19), a mixture of 6beta-hydroxystigmast-4-en-3-one (20) and 6beta-hydroxystigmasta-4,22-dien-3-one (21), and a mixture of beta-sitosterol (22) and stigmasterol (23); and one triterpenoid, i.e., oleanolic acid (24) from the roots of Ficus nervosa. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR as well as MS analyses. Among these isolates, 3-hydroxyxanthyletin (1), genistein (10), prunetin (12), and (2S)-naringenin (15) showed antimycobacterial activities against Mycobacterium tuberculosis H(37)R(V) in vitro with MIC values of 16, 35, 30, and < or =2.8 microg/ml, respectively. |
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Authors:
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Li-Wen Chen; Ming-Jen Cheng; Chien-Fang Peng; Ih-Sheng Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 7 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1814-21 Citation Subset: IM |
Affiliation:
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Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R.O.C. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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chemistry*,
isolation & purification,
pharmacology* Coumarins / chemistry, isolation & purification, pharmacology Ficus / chemistry* Flavonoids / chemistry, isolation & purification, pharmacology Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis / drug effects* Plant Extracts / chemistry*, isolation & purification, pharmacology* Plant Roots / chemistry* Steroids / chemistry, isolation & purification, pharmacology Triterpenes / chemistry, isolation & purification, pharmacology Tuberculosis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Coumarins; 0/Flavonoids; 0/Plant Extracts; 0/Steroids; 0/Triterpenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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