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Second trimester uterine artery Doppler screening in prediction of adverse pregnancy outcome in high risk women.
MedLine Citation:
PMID:  21294407     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To assess the value of uterine artery colour Doppler waveform analysis in the prediction of adverse pregnancy outcome such as preeclampsia, fetal growth restriction in high risk pregnancy women.
MATERIAL AND METHOD: Uterine artery Doppler screening was performed as part of mid trimester screening between 20 and 24 weeks gestation in high risk pregnancy women at Matermal Fetal Medicine unit, Thammasat University Hospital between June 1, 2008 and May 31, 2009. A pulsatility index (PI) was calculated from each uterine artery and the presence or absence of a notch was determined. A PI of > 1.58 or the presence of any diastolic notch were defined as abnormal. The main outcome measures were pre-eclampsia and small for gestational aged baby (birth weight < 10th centile).
RESULTS: Doppler examination of the uterine arteries were performed in 330 singleton pregnancies. Twenty-seven (8.18%) women developed pre-eclampsia, 16 (4.84%) women had SGA babies. The sensitivity ofPI > 1.58 and diastolic notch for preeclampsia, SGA were 59.25% and 56.25%, respectively.The specificity of PI >1.58 and diastolic notch for these outcomes were 66.67% and 65.60% respectively.
CONCLUSION: In high-risk women, mid trimester uterine artery Doppler waveform analysis can not use as screening method in women at higher risk for the development of severe adverse outcome such as pre-eclampsia and SGA babies. However women with normal uterine artery Doppler results are unlikely to develop pre-eclampsia, fetal growth restriction (FGR) and therefore do not necessarily need repeated Doppler ultrasound follow-up.
Densak Pongrojpaw; Athita Chanthasenanont; Tongta Nanthakomon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  93 Suppl 7     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  S127-30     Citation Subset:  IM    
Maternal Fetal Medicine Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
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