| Second-trimester unconjugated oestriol levels in maternal serum from chromosomally abnormal pregnancies using an optimized assay. | |
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MedLine Citation:
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PMID: 7685092 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Second-trimester unconjugated oestriol (UE3) levels were measured retrospectively in maternal serum from 78 chromosomally abnormal pregnancies and 390 matched controls using a radioimmunoassay kit (Amersham AMERLEX-M) optimized for use in the second trimester. Reduced levels of UE3 were found in a group of 49 Down's syndrome pregnancies with a median UE3 level of 0.79 multiples of the median (MOM) of the controls. Four trisomy 18 pregnancies had UE3 levels less than 0.7 MOM. There was a highly significant level of correlation between alpha-fetoprotein (AFP) and UE3 levels in the controls (r = 0.25, p < 0.01), the Down's syndrome pregnancies (r = 0.44, p < 0.01), and the other chromosome abnormalities (r = 0.61, p < 0.01). When used as an additional marker to AFP and human chorionic gonadotrophin in screening for Down's syndrome, UE3 does not appear to add to the sensitivity of such screening. |
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Authors:
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J A Crossley; D A Aitken; J M Connor |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-07-07 Completed Date: 1993-07-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 271-80 Citation Subset: IM |
Affiliation:
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Duncan Guthrie Institute of Medical Genetics, Yorkhill, Glasgow, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations
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blood* Chromosome Disorders Chromosomes, Human, Pair 18 Down Syndrome / blood Estriol / blood* Female Humans Pregnancy / blood* Pregnancy Trimester, Second Radioimmunoassay Retrospective Studies Trisomy alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins; 50-27-1/Estriol |
| Comments/Corrections | |
Comment In:
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Prenat Diagn. 1993 Dec;13(12):1149-53
[PMID:
8018186
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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