Document Detail

Second trimester neutrophil gelatinase-associated lipocalin as a potential prediagnostic marker of preeclampsia.
MedLine Citation:
PMID:  18951213     Owner:  NLM     Status:  MEDLINE    
Neutrophil gelatinase-associated lipocalin (NGAL) concentrations, a product of neutrophils, were investigated in normal and preeclamptic pregnancies. Prospectively collected data and late second trimester (24-26 weeks) serum samples from 48 women who subsequently developed preeclampsia (PE) and 96 control women with uncomplicated pregnancies were compared. Serum NGAL values, as determined by quantitative sandwich enzyme immunoassay, were significantly increased in the preeclamptic compared to the control women: 76.9 ng/ml (interquartile range 39.7-96.5) versus 16.0 ng/ml (interquartile range 11.2-24.4) (p<0.001), and were positively correlated to blood pressure and proteinuria, showing a high sensitivity (75%) and specificity (94.5%). The results suggest that serum NGAL might be involved in the pathophysiology of PE and could be a marker for this syndrome.
Rosario D'Anna; Giovanni Baviera; Domenico Giordano; Giovanna Todarello; Francesco Corrado; Michele Buemi
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1370-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Messina, Italy.
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MeSH Terms
Acute-Phase Proteins
Biological Markers / blood
Birth Weight
Blood Pressure
Case-Control Studies
Infant, Newborn
Lipocalins / blood*
Pre-Eclampsia / blood,  diagnosis*
Pregnancy Trimester, Second / blood*
Proteinuria / blood
Proto-Oncogene Proteins / blood*
Sensitivity and Specificity
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/LCN2 protein, human; 0/Lipocalins; 0/Proto-Oncogene Proteins

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