Document Detail

Second-trimester multifetal pregnancy reduction facilitates prenatal diagnosis before the procedure.
MedLine Citation:
PMID:  10689003     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the pregnancy outcome of selective second-trimester multifetal pregnancy reduction (MFPR) compared to first-trimester MFPR.
DESIGN: Cohort analysis.
SETTING: In Vitro Fertilization Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
PATIENT(S): The study groups comprised 38 and 70 patients who underwent selective second-trimester MFPR (group 1) and first-trimester MFPR (group 2) at mean gestational ages of 19.7 +/- 3.3 weeks and 11.7 +/- 0.7 weeks, respectively.
INTERVENTION(S): Ultrasonographically guided intracardiac injection of potassium chloride (KCl) solution.
MAIN OUTCOME MEASURE(S): Pregnancy outcome and obstetric complications.
RESULT(S): No statistically significant difference was found between group 1 and group 2 regarding mean gestational age at delivery (35.4 +/- 3.4 weeks and 35.9 +/- 3.1 weeks, respectively); mean birth weight (2,318.9 +/- 565.7 g and 2, 138.1 +/- 529.4 g); and the incidence of obstetric complications. These complications included pregnancy loss (5.2% and 15.7%), pregnancy-induced hypertension (0 and 10%), discordancy (12% and 18. 4%), intrauterine growth restriction (0 and 40%), and gestational diabetes (0% and 6%). However, the rate of all pregnancy complications was lower among second-trimester MFPR patients.
CONCLUSION(S): Selective second-trimester MFPR is associated with favorable perinatal outcome and may facilitate detection of structural and chromosomal anomalies before the procedure and selective reduction of the affected fetus.
E Geva; G Fait; I Yovel; L Lerner-Geva; Y Yaron; Y Daniel; A Amit; J B Lessing
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  73     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-23     Completed Date:  2000-03-23     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  505-8     Citation Subset:  IM    
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MeSH Terms
Birth Weight
Cohort Studies
Diabetes, Gestational
Fetal Death / epidemiology
Pregnancy Complications, Cardiovascular
Pregnancy Outcome
Pregnancy Reduction, Multifetal* / statistics & numerical data
Pregnancy Trimester, First
Pregnancy Trimester, Second
Pregnancy, Multiple* / statistics & numerical data
Prenatal Diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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