| Second-trimester maternal serum inhibin A concentration as an early marker for preeclampsia. | |
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MedLine Citation:
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PMID: 10411808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Maternal serum inhibin A concentration is elevated in established preeclampsia. The aim of this study was to investigate whether this relationship antedates the appearance of the classic signs of preeclampsia. STUDY DESIGN: A retrospective analysis was performed on trisomy 21 screening data from 685 women at between 15 and 19 weeks' gestation. The main outcome measures were preeclampsia and small for gestational age (<5th percentile) infants. RESULTS: Preeclampsia developed in 35 women (5.5%). Women with inhibin A concentration >2.0 multiples of the median were significantly more likely to acquire preeclampsia (P <.00001) and to be delivered of a small for gestational age infant (<5th percentile, P <.00001) than were women with inhibin A concentration </=2.0 multiples of the median. The odds ratios were 9.4 (95% confidence interval 4.6-19.3) for development of preeclampsia and 18.2 (95% confidence interval 6. 0-54.8) for preeclampsia necessitating delivery at <37 weeks' gestation. The association remained statistically significant for nulliparous women. CONCLUSION: Elevated maternal inhibin A concentration in the second trimester was strongly associated with a subsequent risk of preeclampsia. The potential role of second trimester inhibin A measurement in a screening strategy for preeclampsia needs to be investigated further. |
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Authors:
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J Aquilina; A Barnett; O Thompson; K Harrington |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 181 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-19 Completed Date: 1999-08-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 131-6 Citation Subset: AIM; IM |
Affiliation:
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Homerton Hospital National Health Service Trust and St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary & Westfield College, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood* Female Humans Inhibins / blood* Odds Ratio Pre-Eclampsia / blood*, diagnosis* Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Prenatal Diagnosis* Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 57285-09-3/Inhibins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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