| Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies. | |
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MedLine Citation:
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PMID: 18785180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the utility of maternal serum ADAM12 as a Down's syndrome marker. METHODS: Samples from 71 Down's syndrome affected pregnancies were retrieved from - 20 degrees C storage together with 710 controls matched for gestation and storage time. ADAM12 was measured prior to identification of the affected pregnancies, and expressed in multiples of the gestation-specific median (MoM). RESULTS: The median ADAM12 level in the affected pregnancies was 1.36 MoM with a 10th-90th centile range of 0.90-1.94 MoM compared with 1.01 and 0.65-1.52 MoM in the unaffected control pregnancies (P = < 0.0001, two-side Wilcoxon Rank Sum Test). The Mahalanobis distance between the medians was 0.96 compared with 0.92, 1.18, 1.07 and 1.24 for alpha-fetoprotein, intact human chorionic gonadotrophin (hCG), unconjugated estriol and inhibin-A respectively in the same samples. In unaffected pregnancies there were highly statistically significant correlations between ADAM12 and each of the other markers; in the affected pregnancies the only significant correlations were with hCG (P< or =0.0001) and inhibin-A (P< or =0.05). Statistical modelling predicted that ADAM12 as a fifth marker could increase the detection rate by 2-3% or reduce the false-positive rate by 0.9-1.7%. CONCLUSIONS: ADAM12 is a second trimester marker of Down's syndrome, with discriminatory power similar to existing markers. It could be considered in multi-marker combinations. |
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Authors:
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Kim Donalson; Steve Turner; Hilary Wastell; Howard Cuckle |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 28 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 904-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Biochemistry Department, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-Upon-Tyne, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADAM Proteins
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blood* Biological Markers / blood* Chorionic Gonadotropin / blood Down Syndrome / blood*, diagnosis Estriol / blood False Positive Reactions Female Humans Inhibins / blood Membrane Proteins / blood* Pregnancy Pregnancy Trimester, Second / blood* Prenatal Diagnosis Retrospective Studies alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin; 0/Membrane Proteins; 0/alpha-Fetoproteins; 0/inhibin A; 50-27-1/Estriol; 57285-09-3/Inhibins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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