Document Detail

Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies.
MedLine Citation:
PMID:  18785180     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the utility of maternal serum ADAM12 as a Down's syndrome marker. METHODS: Samples from 71 Down's syndrome affected pregnancies were retrieved from - 20 degrees C storage together with 710 controls matched for gestation and storage time. ADAM12 was measured prior to identification of the affected pregnancies, and expressed in multiples of the gestation-specific median (MoM). RESULTS: The median ADAM12 level in the affected pregnancies was 1.36 MoM with a 10th-90th centile range of 0.90-1.94 MoM compared with 1.01 and 0.65-1.52 MoM in the unaffected control pregnancies (P = < 0.0001, two-side Wilcoxon Rank Sum Test). The Mahalanobis distance between the medians was 0.96 compared with 0.92, 1.18, 1.07 and 1.24 for alpha-fetoprotein, intact human chorionic gonadotrophin (hCG), unconjugated estriol and inhibin-A respectively in the same samples. In unaffected pregnancies there were highly statistically significant correlations between ADAM12 and each of the other markers; in the affected pregnancies the only significant correlations were with hCG (P< or =0.0001) and inhibin-A (P< or =0.05). Statistical modelling predicted that ADAM12 as a fifth marker could increase the detection rate by 2-3% or reduce the false-positive rate by 0.9-1.7%. CONCLUSIONS: ADAM12 is a second trimester marker of Down's syndrome, with discriminatory power similar to existing markers. It could be considered in multi-marker combinations.
Kim Donalson; Steve Turner; Hilary Wastell; Howard Cuckle
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  28     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  904-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 John Wiley & Sons, Ltd.
Biochemistry Department, Royal Victoria Infirmary, Queen Victoria Road, Newcastle-Upon-Tyne, UK.
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MeSH Terms
ADAM Proteins / blood*
Biological Markers / blood*
Chorionic Gonadotropin / blood
Down Syndrome / blood*,  diagnosis
Estriol / blood
False Positive Reactions
Inhibins / blood
Membrane Proteins / blood*
Pregnancy Trimester, Second / blood*
Prenatal Diagnosis
Retrospective Studies
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/Membrane Proteins; 0/alpha-Fetoproteins; 0/inhibin A; 50-27-1/Estriol; 57285-09-3/Inhibins; EC 3.4.24.-/ADAM 12 protein; EC 3.4.24.-/ADAM Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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