Document Detail

Second trimester maternal dimeric inhibin-A in the multiple-marker screening test for Down's syndrome.
MedLine Citation:
PMID:  9572446     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the additional value of dimeric inhibin-A serum concentration in second trimester multiple-marker screening tests for pregnancies affected by Down's syndrome. We anticipated that second trimester maternal serum dimeric inhibin-A concentrations would be altered in pregnancies complicated by fetal Down's syndrome and that dimeric inhibin-A would perform better than one of the three substances analysed in the multiple-marker screening test currently in use. A total of 1156 serum samples were screened for dimeric inhibin-A in parallel with the routine classic triple test screening programme performed on a random obstetric population. Classic triple test performance was compared with detection rates obtained after substitution of unconjugated oestriol by inhibin-A and with the performance of inhibin-A and alpha-fetoprotein alone. Absolute dimeric inhibin-A maternal serum concentrations of Down's syndrome pregnancies were indeed significantly higher than those of normal pregnancies in our screened population. The performance of dimeric inhibin-A in combination with the multiple-marker screening test, however, is limited because of its strong correlation with intact human chorionic gonadotrophin.
M A Renier; A Vereecken; E Van Herck; D Straetmans; P Ramaekers; P Buytaert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  744-8     Citation Subset:  IM    
University Hospital of Antwerp, Department of Obstetrics and Gynecology, University of Antwerp, Belgium.
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MeSH Terms
Biological Markers*
Chorionic Gonadotropin, beta Subunit, Human / blood
Down Syndrome / blood*
Estriol / blood
False Positive Reactions
Inhibins / blood*
Pregnancy Trimester, Second
Prenatal Diagnosis*
Reference Values
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol; 57285-09-3/Inhibins

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