Document Detail

Second trimester amniotic fluid endothelin-1 concentrations and subsequent development of intrauterine growth restriction.
MedLine Citation:
PMID:  17123690     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this prospective study was to record endothelin-1 (ET-1) concentrations in the second trimester amniotic fluid and compare these values in women who developed intrauterine growth restriction (IUGR) later in pregnancy with those with uneventful pregnancies. METHOD: Amniotic fluid was retrieved by amniocentesis from 125 women in the second trimester of pregnancy. The levels of ET1 were measured by a sensitive and specific radioimmunoassay. RESULTS: From the 125 women included in the study 12 had pregnancies that later developed IUGR and 88 had uneventful pregnancies. The ET1 concentration was significantly higher (P<0.005) in women who later developed IUGR than in normal pregnancy (106 pg/ml versus 64.7 pg/ml). CONCLUSION: The amniotic fluid concentration of ET1 is elevated by the second trimester in women who later develop IUGR.
Lavinia Margarit; Anthony N Griffiths; Vassilios Tsapanos; Sotiris Tsakas; Dimitios Gumenos; George Decavalas
Publication Detail:
Type:  Journal Article     Date:  2006-11-22
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  134     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  192-5     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital of Patras, Greece.
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MeSH Terms
Amniotic Fluid / chemistry*
Biological Markers
Case-Control Studies
Endothelin-1 / analysis,  metabolism*
Fetal Growth Retardation / metabolism*
Pregnancy Trimester, Second
Prospective Studies
Reg. No./Substance:
0/Biological Markers; 0/Endothelin-1

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