Document Detail

Second trimester amniotic fluid adiponectin level is affected by maternal tobacco exposure, insulin, and PAPP-A level.
MedLine Citation:
PMID:  22940118     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. The objectives of the present study were to determine the amniotic fluid (AF) concentration of adiponectin during the second trimester of pregnancy and to demonstrate its association with maternal and fetal variables and AF concentrations of insulin, leptin, and pregnancy-associated-plasma-protein A (PAPP-A).
STUDY DESIGN: We performed a cross-sectional study of 222 pregnant women who underwent amniocentesis at 15-18 weeks for genetic reasons. No malformation or chromosomal disorder was found in the newborn after birth. AF adiponectin, leptin, PAPP-A, and insulin concentrations were measured using commercially available assays. All maternal, fetal, and biochemical variables were studied using univariate and multivariate linear regression analysis to determine their association with the AF concentration of adiponectin.
RESULTS: Adiponectin concentration was negatively correlated with maternal smoking status (β=-5.208; p<0.001) and positively correlated with levels of insulin (β=0.621; p=0.002) and PAPP-A (β=40.150; p<0.001). Non-significant correlations were found between adiponectin concentration and maternal age, maternal body mass index, gestational age at amniocentesis, fetal gender, and AF level of leptin.
CONCLUSION: These findings suggest that the fetus and its membrane adipocytokines, in relationship with maternal and other fetal variables, play a dynamic role in the regulation of energy and oxidative stress homeostasis due to its insulin-sensitizing and antiatherosclerotic effects. The association of these molecules with maternal tobacco consumption during pregnancy could have perinatal implications.
Juan De Leon-Luis; Ricardo Perez; Pilar Pintado Recarte; Alfredo Avellaneda Fernandez; Carlos Romero Roman; Eugenia Antolin Alvarado; Luis Ortiz-Quintana; Maravillas Izquierdo Martinez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-31
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  165     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-16     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics and Gynecology, Hospital Gregorio Marañón, Madrid, Spain.
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MeSH Terms
Adiponectin / metabolism*
Amniotic Fluid / chemistry*
Cross-Sectional Studies
Gestational Age
Infant, Newborn
Insulin / metabolism*
Leptin / metabolism
Maternal Age
Maternal Exposure
Pregnancy Trimester, Second
Pregnancy-Associated Plasma Protein-A / metabolism*
Smoking / adverse effects*
Reg. No./Substance:
0/Adiponectin; 0/Insulin; 0/Leptin; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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