Document Detail

Second trimester amniocentesis in assisted conception versus spontaneously conceived twins.
MedLine Citation:
PMID:  18675413     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the outcome of amniocentesis in twins conceived with assisted reproduction technology (ART) versus spontaneously conceived twins. DESIGN: Retrospective analysis of case records between 1993 and 2006. SETTING: University-affiliated tertiary center for fetal medicine. PATIENT(S): 167 ART twin pregnancies and 275 spontaneous twin pregnancies. INTERVENTION(S): Genetic amniocentesis. MAIN OUTCOME MEASURE(S): Comparison of pregnancy loss rate and perinatal outcome between the ART and spontaneous twin-pregnancy groups. RESULT(S): The fetal loss rate was similar between the two groups (4.2% vs. 4.0% in the ART twins and spontaneous twins, respectively), although the interval between amniocentesis to miscarriage was statistically significantly shorter in the ART twins than the spontaneous twins (6.2 and 20.1 days, respectively). In all cases, fetal loss refers to the loss of the entire pregnancy. The preterm delivery rate before 37 weeks was statistically significantly higher in the ART group (64.1%) compared with controls (49.5%). CONCLUSION(S): Amniocentesis in ART twins carries a fetal loss rate similar to spontaneous twins. However, ART twins have a statistically significantly increased risk of preterm delivery especially before 32 weeks' gestation.
George Daskalakis; Eleftherios Anastasakis; Nikolaos Papantoniou; Spyros Mesogitis; Aris Antsaklis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2572-7     Citation Subset:  IM    
First Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, Athens University, Athens, Greece.
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MeSH Terms
Amniocentesis / methods*
Confidence Intervals
Infant, Newborn
Intensive Care Units, Neonatal / statistics & numerical data
Pregnancy Complications / epidemiology
Pregnancy Trimester, Second*
Reproductive Techniques, Assisted / statistics & numerical data*
Retrospective Studies
Twins / physiology*

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