Document Detail

Second trimester abortion with prostaglandin F2 alpha.
MedLine Citation:
PMID:  6102057     Owner:  NLM     Status:  MEDLINE    
A clinical trial comparing 40-mg and 50-mg, intraamniotic dose schedules of prostaglandin F2 alpha (PGF2 alpha) is described. The trial included 48 patients at 15-20 weeks' gestation, with 20 receiving a 40-mg dose of PGF2 alpha and 28 receiving a 50-mg dose of PGF2 alpha. The success rates for the two groups were 85% and 93%, respectively. All nulliparous patients who had 50 mg of PGF2 alpha and all multiparous patients who had 40 mg of PGF2 alpha aborted within the 48-hour trial period. The mean induction-to-abortion interval with the 50-mg dose was two hours shorter than that with the 40-mg dose. All patients who had 40 mg of PGF2 alpha over 16 weeks' gestation aborted within the trial period. In patients who had 50 mg of PGF2 alpha, the period of gestation did not influence the induction-to-abortion interval. Minor side effects, primarily vomiting or diarrhea, were observed in 65% and 93% of the patients who had 40-mg and 50-mg doses, respectively. We conclude that intraamniotic administration of 50 mg of PGF2 alpha successfully induces midtrimester abortion in nulliparous patients, whereas a 40-mg dose suffices for multiparous women.
T K Chatterjee; L Niles
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  17     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:    1980 Jan-Feb
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-61     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced*
Clinical Trials as Topic
Diarrhea / chemically induced
Drug Administration Schedule
Pregnancy Trimester, Second
Prostaglandins F* / administration & dosage,  adverse effects
Time Factors
Vomiting / chemically induced
Reg. No./Substance:
0/Prostaglandins F

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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