Document Detail

Second trimester abortion with ethacridine lactate plus carboprost--which is the best time to administer the carboprost?
MedLine Citation:
PMID:  3145677     Owner:  NLM     Status:  MEDLINE    
Extra-amniotic ethacridine lactate plus intramuscular prostaglandin has become a popular method for terminating second trimester pregnancies. In this study, intrauterine pressure was continuously monitored in order to objectively compare the efficacy of 3 different times of administration of Carboprost (15-methyl PGF2 alpha) - at 2 hours, 4 hours and 8 hours after the instillation of ethacridine lactate. The best results were obtained with the administration of Carboprost 8 hours after the instillation of the extra-amniotic ethacridine lactate. The synergistic effect of ethacridine lactate and Carboprost is optimal after this time. This is probably because the ethacridine lactate will have produced sufficient cervical ripening to ensure optimal efficacy of the prostaglandin-induced uterine contractions in expelling the products of conception.
A Malpani; A Malpani; U Krishna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in contraception : the official journal of the Society for the Advancement of Contraception     Volume:  4     ISSN:  0267-4874     ISO Abbreviation:  Adv Contracept     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1989-02-10     Completed Date:  1989-02-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607435     Medline TA:  Adv Contracept     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, K.E.M. Hospital, Bombay, India.
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MeSH Terms
Abortifacient Agents*
Abortifacient Agents, Nonsteroidal*
Abortion, Induced*
Acridines* / analogs & derivatives
Drug Administration Schedule
Ethacridine* / analogs & derivatives
Pregnancy Trimester, Second
Prostaglandins F, Synthetic*
Uterine Contraction / drug effects
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Nonsteroidal; 0/Acridines; 0/Prostaglandins F, Synthetic; 35700-23-3/Carboprost; 442-16-0/Ethacridine

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