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Second trimester Maternal Serum Alpha-fetoprotein (MSAFP) as predictor of fetal hemoglobin Bart's disease.
MedLine Citation:
PMID:  25046597     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate the efficacy of MSAFP levels in predicting hemoglobin (Hb) Bart's fetus.
MATERIALS AND METHODS: A total of 199 pregnancies at risk of fetal Hb Bart's disease at 18-22 weeks were enrolled. Before performing cordocentesis for the Hb typing analysis, the MSAFP levels were analyzed and sonographic markers (middle cerebral artery peak systolic velocity, cardiothoracic ratio and placental thickness) were measured. The detection rates of MSAFP and the sonographic markers in predicting fetuses affected by Hb Bart's disease were evaluated.
RESULTS: The MSAFP levels were significantly higher in pregnant women carrying affected fetuses (47 cases) than in those with unaffected fetuses (2.09 MoM vs 1.18 MoM, P < 0.001). MSAFP as a single marker effectively predicted fetal Hb Bart's disease (AUC ROC 0.832, 95% CI 0.752-0.911), with 87.2% sensitivity and 74.5% specificity using a cut-off value greater than 1.50 MoM. A combination of MSAFP with sonographic markers gave detection rates in the range of 91.5-100%.
CONCLUSION: Second trimester MSAFP levels are significantly higher in pregnancies with Hb Bart's fetus. MSAFP as a single marker is relatively effective in Hb Bart's prenatal screening. A high detection rate is achieved when MSAFP is used in combination with sonographic markers. This article is protected by copyright. All rights reserved.
Fuanglada Tongprasert; Kasemsri Srisupundit; Suchaya Luewan; Theera Tongsong
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-21
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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