Document Detail


Second-trimester Down syndrome maternal serum marker screening: a prospective study of 11 040 twin pregnancies.
MedLine Citation:
PMID:  19003979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the value of Down syndrome (DS) second-trimester maternal serum screening in large series of twin pregnancies. METHODS: Prospective study of second-trimester maternal serum markers [alpha fetoprotein (AFP) and free beta-human chorionic gonadotrophin (beta-hCG)] in 11,040 twin pregnancies, 27 of which were trisomy 21-affected. Comparison with 64,815 singleton pregnancies, of which 86 were trisomy 21-affected. Markers were expressed in multiple of median (MoM) corrected by a previously defined coefficient (2.1 for AFP and 2.07 or 2.16 for free beta-hCG, dichorionic or monochorionic, respectively). RESULTS: Trisomy 21 frequency was 1/649 for twins and 1/754 in singletons (NS). Mean detection rate was 63% (71% when both twins were affected and 60% when one was affected), versus 74.4% in singletons. False-positive rates were 10.8% in twins versus 10.3% in singletons (NS). No significant differences in MoM AFP and free beta-hCG values were noted between twins and singletons (0.92 and 0.78 for AFP and 1.54 and 2.68 for free beta-hCG, respectively). CONCLUSION: Our study demonstrates that second-trimester DS maternal serum marker screening can be performed in twin pregnancies.
Authors:
Aurélie Garchet-Beaudron; Sophie Dreux; Nathalie Leporrier; Jean-François Oury; Françoise Muller; ;
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Twin Study    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  28     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1105-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 John Wiley & Sons, Ltd.
Affiliation:
Biochimie-Hormonologie, Hôpital Robert Debré, AP-HP, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers / blood*
Diseases in Twins / diagnosis
Down Syndrome / diagnosis*,  epidemiology
Female
Humans
Incidence
Mothers*
Pregnancy
Pregnancy Trimester, Second / blood*
Pregnancy, Multiple / blood
Prenatal Diagnosis / methods*
Prospective Studies
Twins
Chemical
Reg. No./Substance:
0/Biological Markers
Investigator
Investigator/Affiliation:
C Lemay / ; J M Bourdrel / ; V Gras / ; T Roudon / ; J Y Real / ; P Dumas / ; E Ruedas / ; J Souby / ; P Andlauer / ; E Gaeremynck / ; B Duchene / ; F Barba / ; C Pomel / ; B Dingeon / ; C Doche / ; I Peraud / ; H Chahine / ; C Finot / ; M H Ramaorasy / ; H Lallaoui / ; P Clement / ; L Lohman / ; M Mintz / ; E Berreville / ; P Sigogneau / ; F Duprey / ; G Couplet / ; A Mainardi / ; T Chianea / ; B Veyrat / ; A Piedimonte / ; C Sault / ; F Roux / ; A Boulbina / ; Caparros Giorgetti / ; M Sainte-Rose / ; M E Larcher / ; M Wasel / ; O Michotey / ; A Baret / ; S Mirallie / ; Delpech / ; M Cabrol / ; L Got / ; E Choblet / ; Y Barguil / ; I Czerkiewicz / ; S Dreux / ; F Muller / ; D Khalfon / ; G Cassuto / ; B Brethome / ; M T Panneciere / ; S Palleau / ; J C Aidenbaum / ; C Hamberger / ; L Druart / ; M Bernard / ; C Brochet / ; C Millet / ; M P Bounaud / ; P Guiardiola / ; P Antoine / ; G Belot / ; A Chamson / ; H Mulot / ; C Roy / ; F Fortenfant / ; A Blancher / ; D Dudragne / ; B Cara / ; P Duchateau / ; H Odaert / ; Angotti-Jalladeau / ; C Touboul / ; B Le Fiblec / ; A-M Frances / ; D Luton / ; D Mahieu-Caputo / ; M Uzan / ; Jean Verdier / ; Y Dumez / ; B Carbone / ; F Lewin / ; S Uzan / ; J M Jouannic /

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