| Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies. | |
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MedLine Citation:
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PMID: 14678084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Poor placentation may perpetuate preeclampsia, but the presence of a major placental pathology has been questioned in cases of preeclampsia where the newborn has an appropriate birthweight for gestational age. On the other hand, poor placentation is also observed in the absence of preeclampsia, in pregnancies with small-for-gestational-age (SGA) fetuses. In late gestation, maternal serum levels of placental protein hormones are changed in both preeclampsia and SGA, but no longitudinal pre-onset studies are available for pregnancy-associated plasma protein A (PAPP-A), pregnancy-specific beta1-glycoprotein (SP1) or human placental lactogen (HPL). METHODS: In a nested case-control study we compared maternal serum levels of PAPP-A, SP1, HPL and placenta growth factor (PLGF) at 17, 25 and 33 weeks in pregnancies developing preeclampsia without fetal growth restriction (n = 28), or characterized by a growth-retarded fetus (n = 25), with gestation-matched controls (n = 65). The proteins were quantified using microplate enzyme immunometric assays and the serum levels at 17, 25 and 33 weeks compared between the three groups by nonparametric statistical tests. RESULTS: In pregnancies with subsequent preeclampsia PAPP-A, SP1, HPL and PLGF were reduced at 17 weeks of gestation whereas at 25 and 33 weeks only PLGF remained below the controls. In growth-restricted pregnancies PAPP-A, SP1 and HPL were reduced at 17 weeks, and only HPL continued to be strongly affected thereafter. CONCLUSION: The reduced serum levels of the placental proteins PAPP-A, SP1 and HPL in the early second trimester (17 weeks) in pregnancies with subsequent preeclampsia or with fetal growth restriction involve an underlying role for the placenta in either pathology independent from the other. |
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Authors:
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Nick A Bersinger; Rønnaug A Ødegård |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 83 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-17 Completed Date: 2004-02-12 Revised Date: 2009-11-25 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 37-45 Citation Subset: IM |
Affiliation:
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University Department of Obstetrics and Gynaecology, Reproductive and Perinatal Medicine, Research Laboratory, University of Berne, Insespital KKL G3-825, Berne CH-3010, Switzerland. nick.bersinger@dkf2.unibe.ch |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Case-Control Studies Female Fetal Growth Retardation / blood* Humans Placental Lactogen / blood Pre-Eclampsia / blood* Pregnancy Pregnancy Proteins / blood* Pregnancy Trimester, Second / blood Pregnancy Trimester, Third / blood Pregnancy-Associated Plasma Protein-A / metabolism Pregnancy-Specific beta 1-Glycoproteins / metabolism Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins; 144589-93-5/placenta growth factor; 9035-54-5/Placental Lactogen; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
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