| Second prize: in-vivo physiological impact of alpha blockade on the porcine ureter with distal ureteral obstruction. | |
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MedLine Citation:
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PMID: 21401393 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Purpose: Alpha blockade has been well described clinically for expulsion of distal ureteral stone. However, the in-vivo effects of α-blockade on ureteral dynamics during stone passage are not clear. We studied the effects of oral alfuzosin on ureteral pressure and peristalsis in a distally obstructed porcine ureter. Methods: Twenty-four female domestic swine (75-82 kg) were incorporated into the study. The study was powered to detect a 30% difference in distal ureteral pressure, with a secondary endpoint of frequency of ureteral peristalsis. The animals were divided into four equal groups: a control group without α-blockade or ureteral obstruction, a group with α-blockade and no ureteral obstruction, a cohort without α-blockade but with distal ureteral obstruction, and a group with α-blockade and distal obstruction. Peristalsis was measured by a magnetic sensor and ureteral pressure through a 5F ureteral balloon catheter. Observations were recorded for 10-minute intervals every hour for 5 consecutive hours. Results: There was increase in ureteral pressure and peristaltic rate with distal ureteral obstruction (p < 0.01). Alpha blockade did not produce significant changes in the above parameters with or without ureteral obstruction compared with the nonmedicated groups. We observed a 0.2 mm Hg lower increase in change of ureteral pressure during peristalsis compared with resting ureteral pressure (delta pressure) in the treated obstructed model (95% confidence interval: -0.55 -0.10; p = 0.06). Conclusions: In the porcine model, alfuzosin appears to decrease the delta pressure in the distal ureter during obstruction; however, statistical significance was not reached. Further investigation into the in-vivo physiology of medical expulsive therapy is warranted. |
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Authors:
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Jay Blain Page; Suzanne Humphreys; Daniel Davenport; Paul Crispen; Ramakrishna Venkatesh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endourology / Endourological Society Volume: 25 ISSN: 1557-900X ISO Abbreviation: J. Endourol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807503 Medline TA: J Endourol Country: United States |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Affiliation:
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1 Division of Urology, University of Kentucky , Lexington, Kentucky. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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