Document Detail

Second pregnancy outcomes following preeclampsia in a first pregnancy.
MedLine Citation:
PMID:  16036400     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We compared second pregnancy outcomes among women with and without preeclampsia in their first pregnancies who all had second pregnancies without preeclampsia.
METHODS: One hundred thirty women with and 6148 without preeclampsia in their first pregnancies, who all had nonpreeclamptic second pregnancies, were included. Outcomes, including delivery gestational age, birthweight, small-for-gestational-age (SGA), and preterm delivery were compared.
RESULTS: Overall, second pregnancy outcomes were not different between women with and without preeclampsia in their first pregnancy. However, when women were stratified by gestational timing of preeclampsia, women with preeclampsia at < 34 weeks (N = 22) had smaller infants and delivered earlier in their second nonpreeclamptic pregnancy compared to women with later preeclampsia (N = 108) or no preeclampsia in the first pregnancy. Women with early preeclampsia also had an increased risk of prematurity (< 37 weeks) in second pregnancies that persisted after controlling for confounding factors [Odds ratio (OR = 3.2)].
DISCUSSION: Second, nonpreeclamptic pregnancy outcomes are different between women with previous early preeclampsia and controls but not between late preeclampsia and controls. These findings support other epidemiological data indicating differences between early and late onset preeclampsia as well as a potential relationship of preeclampsia and spontaneous preterm birth.
Kristine Y Lain; Marijane A Krohn; James M Roberts
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  24     ISSN:  1064-1955     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-09-01     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-69     Citation Subset:  IM    
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MeSH Terms
Infant, Newborn
Logistic Models
Pre-Eclampsia / complications*
Pregnancy Outcome*
Premature Birth
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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