Document Detail


Second harmonic generation microscopy as a powerful diagnostic imaging modality for human ovarian cancer.
MedLine Citation:
PMID:  23024013     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study we showed that second-harmonic generation (SHG) microscopy combined with precise methods for images evaluation can be used to detect structural changes in the human ovarian stroma. Using a set of scoring methods (alignment of collagen fibers, anisotropy, and correlation), we found significant differences in the distribution and organization of collagen fibers in the stroma component of serous, mucinous, endometrioid and mixed ovarian tumors as compared with normal ovary tissue. This methodology was capable to differentiate between cancerous and healthy tissue, with clear cut distinction between normal, benign, borderline, and malignant tumors of serous type. Our results indicated that the combination of different image-analysis approaches presented here represent a powerful tool to investigate collagen organization and extracellular matrix remodeling in ovarian tumors (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).
Authors:
Javier Adur; Vitor B Pelegati; Andre A de Thomaz; Mariana O Baratti; Liliana A L A Andrade; Hernandes F Carvalho; Fátima Bottcher-Luiz; Carlos Lenz Cesar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Journal of biophotonics     Volume:  -     ISSN:  1864-0648     ISO Abbreviation:  J Biophotonics     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318567     Medline TA:  J Biophotonics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Biomedical Lasers Application Laboratory, Optics and Photonics Research Center, "Gleb Wataghin" Institute of Physics, State University of Campinas (UNICAMP), Brazil; Microscopy Laboratory Applied to Molecular and Cellular Studies, School of Bioengineering, National University of Entre Ríos (UNER), Ruta 11 Km10, Oro Verde 3101, Entre Ríos, Argentina. jadur@bioingenieria.edu.ar.
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