Document Detail


"Second generation" prostaglandins: midtrimester pregnancy termination by intramuscular injection of a 15-methyl analog of prostaglandin F2alpha.
MedLine Citation:
PMID:  1245238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eighty midtrimester gravid patients were treated with prostaglandin 15(S)-15-methyl Fa alpha by repeated intramuscular injections of 250 mug at 2-hour intervals for the elective termination of pregnancy. A success rate of 97.5% was achieved, with a mean initiation-to-abortion time of 17.2 +/- 1.0 hours. Gastrointestinal side effects were prominent but no serious complications occurred. Serial serum progesterone determinations and continuous intra-amniotic pressure recording were carried out in selected cases and correlated with abortifacient activity. This method of pregnancy termination appears particularly suitable for use in the early midtrimester of gestation.
Authors:
J Robins; L I Mann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  27     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Abortion, Induced*
Adolescent
Adult
Female
Humans
Injections, Intramuscular
Pregnancy
Pregnancy Trimester, Second
Progesterone / blood
Prostaglandins F / administration & dosage*,  adverse effects
Time Factors
Chemical
Reg. No./Substance:
0/Prostaglandins F; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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