Document Detail

"Second generation" prostaglandins: midtrimester pregnancy termination by intramuscular injection of a 15-methyl analog of prostaglandin F2alpha.
MedLine Citation:
PMID:  1245238     Owner:  NLM     Status:  MEDLINE    
Eighty midtrimester gravid patients were treated with prostaglandin 15(S)-15-methyl Fa alpha by repeated intramuscular injections of 250 mug at 2-hour intervals for the elective termination of pregnancy. A success rate of 97.5% was achieved, with a mean initiation-to-abortion time of 17.2 +/- 1.0 hours. Gastrointestinal side effects were prominent but no serious complications occurred. Serial serum progesterone determinations and continuous intra-amniotic pressure recording were carried out in selected cases and correlated with abortifacient activity. This method of pregnancy termination appears particularly suitable for use in the early midtrimester of gestation.
J Robins; L I Mann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  27     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-9     Citation Subset:  IM    
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MeSH Terms
Abortion, Induced*
Injections, Intramuscular
Pregnancy Trimester, Second
Progesterone / blood
Prostaglandins F / administration & dosage*,  adverse effects
Time Factors
Reg. No./Substance:
0/Prostaglandins F; 57-83-0/Progesterone

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