Document Detail

Second cancers following non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  2004317     Owner:  NLM     Status:  MEDLINE    
The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed/expected [O/E] = 1.18; O = 1231). The O/E ratio increased significantly with time to reach 1.77 in 10-year survivors. Significant excesses were noted for acute nonlymphocytic leukemia (O/E = 2.88), cancers of the bladder (O/E = 1.30), kidney (O/E = 1.47), and lung (O/E = 1.57), malignant melanoma (O/E = 2.44), and Hodgkin's disease (O/E = 4.16). Chemotherapy appeared related to subsequent acute nonlymphocytic leukemia (ANLL) and bladder cancer. Radiation therapy was associated with ANLL and possibly cancers of the lung, bladder, and bone. Malignant melanoma was not clearly related to initial NHL treatment.
L B Travis; R E Curtis; J D Boice; B F Hankey; J F Fraumeni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  67     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-04-22     Completed Date:  1991-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2002-9     Citation Subset:  AIM; IM    
Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892.
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MeSH Terms
Antineoplastic Agents / adverse effects
Combined Modality Therapy
Follow-Up Studies
Lymphoma, Non-Hodgkin / therapy*
Middle Aged
Neoplasm Staging
Neoplasms, Multiple Primary / epidemiology*,  etiology,  pathology
Neoplasms, Radiation-Induced / epidemiology,  pathology
Risk Factors
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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