Document Detail


Second trimester estimated fetal weight and fetal weight gain predict childhood obesity.
MedLine Citation:
PMID:  22682615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the extent to which fetal weight during mid-pregnancy and fetal weight gain from mid-pregnancy to birth predict adiposity and blood pressure (BP) at age 3 years.
STUDY DESIGN: Among 438 children in the Project Viva cohort, we estimated fetal weight at 16-20 (median 18) weeks' gestation using ultrasound biometry measures. We analyzed fetal weight gain as change in quartile of weight from the second trimester until birth, and we measured height, weight, subscapular and triceps skinfold thicknesses, and BP at age 3.
RESULTS: Mean (SD) estimated weight at 16-20 weeks was 234 (30) g and birth weight was 3518 (420) g. In adjusted models, weight estimated during the second trimester and at birth were associated with higher body mass index (BMI) z-scores at age 3 years (0.32 unit [95% CI, 0.04-0.60 unit] and 0.53 unit [95% CI, 0.24-0.81 unit] for the highest vs lowest quartile of weight). Infants with more rapid fetal weight gain and those who remained large from mid-pregnancy to birth had higher BMI z-scores (0.85 unit [95% CI, 0.30-1.39 unit] and 0.63 unit [95% CI, 0.17-1.09 unit], respectively) at age 3 than did infants who remained small during fetal life. We did not find associations between our main predictors and sum or ratio of subscapular and triceps skinfold thicknesses or systolic BP.
CONCLUSION: More rapid fetal weight gain and persistently high fetal weight during the second half of gestation predicted higher BMI z-score at age 3 years. The rate of fetal weight gain throughout pregnancy may be important for future risk of adiposity in childhood.
Authors:
Margaret Parker; Sheryl L Rifas-Shiman; Emily Oken; Mandy B Belfort; Vincent W V Jaddoe; Matthew W Gillman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-06-07
Journal Detail:
Title:  The Journal of pediatrics     Volume:  161     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-10     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  864-70     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Biometry
Birth Weight
Blood Pressure
Body Mass Index
Body Weight
Child, Preschool
Cohort Studies
Female
Fetal Weight
Humans
Infant, Newborn
Male
Multivariate Analysis
Obesity / diagnosis*,  etiology
Pregnancy
Ultrasonography, Prenatal / methods
Weight Gain
Grant Support
ID/Acronym/Agency:
HD-034568/HD/NICHD NIH HHS; HL-068041/HL/NHLBI NIH HHS; HL-64925/HL/NHLBI NIH HHS; K24 HD069408/HD/NICHD NIH HHS; K24 HL068041/HL/NHLBI NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HL064925/HL/NHLBI NIH HHS
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