| Second Messengers cAMP, Ca(2+), and NO Modulate Functional Properties of Human Lymphocytes under Conditions of Exposure to UV Light. | |
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MedLine Citation:
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PMID: 22235420 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We studied the effect of UV light (240-390 nm) in doses of 75.5-4530 J/m(2)on functional properties and level of intracellular messengers (cAMP, Ca(2+), NO) in lymphocytic cells of the peripheral blood. Correcting effects of UV light in a dose of 151 J/m(2)on cytotoxic activity of lymphocytes against Ehrlich ascetic carcinoma and calcium concentration in lymphocyte cytosol were observed. We found that UV light reduces the cAMP content and increases NO concentration (151-4530 J/m(2)) in photomodified cells. The involvement of adenylate cyclase and phosphoinositide signaling pathway into the mechanisms of modulation of functional properties of lymphocytes after exposure to UV light was demonstrated. |
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Authors:
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M A Nakvasina; O V Lidokhova; L I Popova; M S Trubitsyna; V G Artyukhov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 150 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2012-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng; rus Pagination: 696-9 Citation Subset: IM |
Affiliation:
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Voronezh State University, Russia. avg@main.vsu.ru. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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