Document Detail

Second Messenger Regulation of Biofilm Formation: Breakthroughs in Understanding c-di-GMP Effector Systems.
MedLine Citation:
PMID:  23057745     Owner:  NLM     Status:  In-Data-Review    
The second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP) has emerged as a broadly conserved intracellular signaling molecule. This soluble molecule is important for controlling biofilm formation, adhesion, motility, virulence, and cell morphogenesis in diverse bacterial species. But how is the typical bacterial cell able to coordinate the actions of upward of 50 proteins involved in synthesizing, degrading, and binding c-di-GMP? Understanding the specificity of c-di-GMP signaling in the context of so many enzymes involved in making, breaking, and binding the second messenger will be possible only through mechanistic studies of its output systems. Here we discuss three newly characterized c-di-GMP effector systems that are best understood in terms of molecular and structural detail. As they are conserved across many bacterial species, they likely will serve as central paradigms for c-di-GMP output systems and contribute to our understanding of how bacteria control critical aspects of their biology.
Chelsea D Boyd; George A O'Toole
Related Documents :
23486475 - Small heat shock protein ibpb acts as a robust chaperone in living cells by hierarchica...
23346375 - Selection of nanobodies that target human neonatal fc receptor.
23708605 - Electron microscopy structure of human apc/c(cdh1)-emi1 reveals multimodal mechanism of...
24312095 - Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition.
6277655 - The effect of gtp on benzodiazepine receptors.
16032975 - Multiple biological activities of the mammalian protein hap46/bag-1.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  28     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  439-62     Citation Subset:  IM    
Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755; email:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bioengineering methods for analysis of cells in vitro.
Next Document:  Functional diversity of laminins.