Document Detail

Sebaceous gland and sweat gland carcinomas of the skin. Clinicopathological study and significance of c-erbB-2 oncoprotein expression.
MedLine Citation:
PMID:  1360186     Owner:  NLM     Status:  MEDLINE    
Thirteen sebaceous gland carcinomas and 10 sweat gland carcinomas were examined to elucidate any important histological parameters influencing their prognosis, and the relationship between immunohistochemical expressions of c-erbB-2 oncoprotein and survival of the patients was analyzed. Sebaceous gland carcinomas with vacuolated cytoplasm in more than 50% of whole tumor area, with necrosis, and without lymphoid cell infiltration in tumor nests and stroma had a higher incidence of tumor recurrence and tumor-related death than tumors with vacuolated cytoplasm in 50% or less of whole tumor area (p < 0.01), without necrosis, and with lymphoid cell infiltration in tumor nest and stroma (p < 0.05). Sweat gland carcinomas of all cases with fatal outcomes demonstrated tubular differentiation in 20% or less of whole tumor area, lymphatic permeation and desmoplastic reaction. Three sebaceous gland carcinomas and three sweat gland carcinomas were positive for c-erbB-2 oncoprotein. Two of three sebaceous gland carcinomas, and all three sweat gland carcinomas developed tumor recurrence and ended in tumor-related deaths. Sweat gland carcinomas with c-erbB-2 expression had significantly shorter survival than those with negative immunostain (p < 0.01). Cytoplasmic appearance, tumor necrosis, and lymphoid cell infiltration in tumor nests and stroma of sebaceous gland carcinoma, and tubular differentiation, lymphatic permeation, and growth patterns of sweat gland carcinoma are considered to closely correlate to the prognosis. Immunohistochemically detected c-erbB-2 oncoprotein may be an indicator of bad prognosis.
T Hasebe; K Mukai; K Ishihara; A Kaneko; Y Shimosato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pathologica japonica     Volume:  42     ISSN:  0001-6632     ISO Abbreviation:  Acta Pathol. Jpn.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-29     Completed Date:  1992-12-29     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0372637     Medline TA:  Acta Pathol Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  585-94     Citation Subset:  IM    
Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Carcinoma / metabolism,  pathology*
Middle Aged
Proto-Oncogene Proteins / metabolism*
Receptor, erbB-2
Sebaceous Glands*
Skin Diseases / metabolism,  pathology
Sweat Gland Neoplasms / metabolism,  pathology*
Reg. No./Substance:
0/Proto-Oncogene Proteins; EC, erbB-2

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