Document Detail


Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study.
MedLine Citation:
PMID:  18396014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sebaceous carcinoma (SC) is a rare malignancy, affecting mainly the periocular glands. To the best of the authors' knowledge, this is the first English-language report of parotid SC affecting children; two cases are presented. Immunohistochemical studies included 29 different antibodies (15 of these were cytokeratins, CKs). For each case, DNA ploidy status was determined using isolated nuclei stained with Feulgen and analysed using a DNA image cytometry system. Most of the tumour cells were positive for CKs AE1/AE3, 34B12, 5 and 7. The CK14 pattern depicted the monolayer of basal cells surrounding the islands of malignant tissue, while the more central sebaceous differentiated cells were negative. Epithelial membrane antigen was strongly positive in the well differentiated cells, while most of the basaloid peripheral cells were negative, and only a few cells were positive for carcinoembryonic antigen. beta catenin, E cadherin and C-erb B2 were expressed by most of the cells including the more differentiated sebaceous cells. Tumour cells were negative for muscle or myoepithelial markers, androgen, oestrogen and progesterone receptors. Both SCs were uniformly diploid, and showed low proliferative indices for p53, Ki-67 and Mcm-2, which is consistent with the good clinical course presented by these patients so far.
Authors:
A Altemani; P A Vargas; I Cardinali; S S Aguiar; M Lopes; A B Soares; P M Speight; O P Almeida
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  37     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-09-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  D; IM    
Affiliation:
Department of Pathology, Medical School, State University of Campinas-UNICAMP, Campinas-SP, Brazil. aaltemani@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma, Sebaceous / chemistry*,  genetics,  pathology
Cadherins / analysis
Child
Diploidy
Female
Humans
Keratin-14 / analysis
Keratin-18 / analysis
Keratin-19 / analysis
Male
Mucin-1 / analysis
Parotid Neoplasms / chemistry*,  genetics,  pathology
Prognosis
Receptor, erbB-2 / analysis
beta Catenin / analysis
Chemical
Reg. No./Substance:
0/Cadherins; 0/Keratin-14; 0/Keratin-18; 0/Keratin-19; 0/Mucin-1; 0/beta Catenin; EC 2.7.10.1/Receptor, erbB-2

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