Document Detail


Sebaceous adenomas in an MYH associated polyposis patient of Indian (Gujarati) origin.
MedLine Citation:
PMID:  17874208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MYH associated polyposis is an autosomal recessive polyposis syndrome with a high risk of large bowel cancer, caused by mutations in the DNA repair gene MYH. Founder mutations have been described in different ethnic groups. Muir Torre Syndrome is the association of internal malignancies with sebaceous gland tumours; Lynch Syndrome/Hereditary Non Polyposis Cancer is the best known cause. There has been a previous report of sebaceous gland tumours in an Italian patient with MYH associated polyposis. We describe a man of Indian (Gujarati) descent who has MYH associated polyposis and multiple sebaceous adenomas of the skin.
Authors:
Vadakke Kanakath Ajith Kumar; June Anne Gold; Eleanor Mallon; Shyamala Thomas; Shirley V Hodgson
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-09-15
Journal Detail:
Title:  Familial cancer     Volume:  7     ISSN:  1389-9600     ISO Abbreviation:  Fam. Cancer     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-10-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898211     Medline TA:  Fam Cancer     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  187-9     Citation Subset:  IM    
Affiliation:
North East Thames Regional Genetics Service, Great Ormond Street Hospital, London WC1N 3JH, UK. KumarA@gosh.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adenoma / diagnosis,  genetics*
Adenomatous Polyposis Coli / complications,  diagnosis,  genetics*
DNA Glycosylases / genetics*
Humans
India
Male
Middle Aged
Mutation
Risk Factors
Sebaceous Gland Neoplasms / diagnosis,  etiology,  genetics*
Chemical
Reg. No./Substance:
EC 3.2.2.-/DNA Glycosylases; EC 3.2.2.-/mutY adenine glycosylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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