Document Detail

Sebaceous adenoma of oral cavity: report of case and comparative proliferation study with sebaceous gland hyperplasia and Fordyce's granules.
MedLine Citation:
PMID:  14629335     Owner:  NLM     Status:  MEDLINE    
Sebaceous adenoma (SA) is a rare solitary tumour with a predilection for the forehead and scalp. In the English literature, less than 10 cases of SA have been described in the oral cavity. The objective of this study was to examine the clinicopathologic features and evaluate the expression of epidermal growth factor and its receptor, estrogen receptor and androgen receptor in SA and in its differential diagnoses including sebaceous gland hyperplasia (SGH) and Fordyce's granules (FG). Additionally, we analysed the proliferative potential of sebaceous cells from SA, SGH and FG by measuring proliferating cell nuclear antigen (PCNA) expression and quantification of argyrophilic nuclear organizer regions (AgNORs). The SA showed many clinicopathologic similarities to cases previously reported including the biphasic population of cells, in the periphery of lobules undifferentiated basaloid cells whereas the central area was formed by mature sebocytes. SA was composed of 198 lobules of sebaceous cells, whereas SGH and FG showed a mean of 21 +/- 7.81 and 5.84 +/- 2.83, respectively. The AgNOR and PCNA indices were similar in SA, SGH and FG. These data suggest that lobule counts may be used as additional criteria in distinguishing SA of the oral cavity from other intraoral sebaceous gland lesions.
E Kaminagakura; C R Andrade; A L C A Rangel; R D Coletta; E Graner; O P Almeida; P A Vargas
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oral diseases     Volume:  9     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-01-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  D    
Department of Oral Pathology, University of Campinas, Dental School, Piracicaba-SP, Brazil.
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MeSH Terms
Adenoma / pathology*
Aged, 80 and over
Choristoma / pathology*
Diagnosis, Differential
Epidermal Growth Factor / analysis
Middle Aged
Mouth Diseases / pathology*
Mouth Neoplasms / pathology*
Nucleolus Organizer Region / ultrastructure
Proliferating Cell Nuclear Antigen / analysis
Receptor, Epidermal Growth Factor / analysis
Receptors, Androgen / analysis
Receptors, Estrogen / analysis
Sebaceous Glands / pathology*
Sweat Glands / pathology*
Reg. No./Substance:
0/Proliferating Cell Nuclear Antigen; 0/Receptors, Androgen; 0/Receptors, Estrogen; 62229-50-9/Epidermal Growth Factor; EC, Epidermal Growth Factor

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