Document Detail

The Seattle longitudinal prospective study on alcohol and pregnancy.
MedLine Citation:
PMID:  7254467     Owner:  NLM     Status:  MEDLINE    
An unselected sample of 1529 women (predominantly white, married, and middle-class) were interviewed during pregnancy regarding their use of alcohol, nicotine, caffeine, drugs, and other variables. Subsets of offspring were examined to assess the relationship of self-reported maternal alcohol use to infant health and development. Multiple regression statistical tests were utilized to permit adjustment for other possibly confounding factors. The following are among those outcomes significantly related to increase maternal alcohol use after adjusting for smoking and other variables: smaller infant size (birth weight, length and head circumference); lower Apgar scores; poorer neonatal habituation; decreased sucking pressure; increased tremulousness and head-turns-to-left; decreased vigorous activity; and a higher frequency of minor dysmorphic characteristics combined with low birth weight and microcephaly. A drinking by smoking interaction was related to poorer newborn conditioning in two separate studies. Significantly lower mental and motor development and lower length and weight were found on follow-up of 468 infants at age 8 months. Follow-up studies continue.
A P Streissguth; D C Martin; J C Martin; H M Barr
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobehavioral toxicology and teratology     Volume:  3     ISSN:  0275-1380     ISO Abbreviation:  Neurobehav Toxicol Teratol     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104162     Medline TA:  Neurobehav Toxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking*
Alcoholic Beverages / adverse effects*
Breast Feeding
Child Behavior / drug effects
Conditioning, Operant / drug effects
Fetal Alcohol Syndrome / etiology
Fetus / drug effects*
Growth / drug effects
Infant, Newborn
Longitudinal Studies
Prospective Studies
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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