| The Seattle longitudinal prospective study on alcohol and pregnancy. | |
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MedLine Citation:
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PMID: 7254467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An unselected sample of 1529 women (predominantly white, married, and middle-class) were interviewed during pregnancy regarding their use of alcohol, nicotine, caffeine, drugs, and other variables. Subsets of offspring were examined to assess the relationship of self-reported maternal alcohol use to infant health and development. Multiple regression statistical tests were utilized to permit adjustment for other possibly confounding factors. The following are among those outcomes significantly related to increase maternal alcohol use after adjusting for smoking and other variables: smaller infant size (birth weight, length and head circumference); lower Apgar scores; poorer neonatal habituation; decreased sucking pressure; increased tremulousness and head-turns-to-left; decreased vigorous activity; and a higher frequency of minor dysmorphic characteristics combined with low birth weight and microcephaly. A drinking by smoking interaction was related to poorer newborn conditioning in two separate studies. Significantly lower mental and motor development and lower length and weight were found on follow-up of 468 infants at age 8 months. Follow-up studies continue. |
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Authors:
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A P Streissguth; D C Martin; J C Martin; H M Barr |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurobehavioral toxicology and teratology Volume: 3 ISSN: 0275-1380 ISO Abbreviation: Neurobehav Toxicol Teratol Publication Date: 1981 |
Date Detail:
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Created Date: 1981-09-15 Completed Date: 1981-09-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8104162 Medline TA: Neurobehav Toxicol Teratol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 223-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking* Alcoholic Beverages / adverse effects* Breast Feeding Child Behavior / drug effects Conditioning, Operant / drug effects Female Fetal Alcohol Syndrome / etiology Fetus / drug effects* Growth / drug effects Humans Infant Infant, Newborn Longitudinal Studies Pregnancy Prospective Studies Washington |
| Grant Support | |
ID/Acronym/Agency:
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5R01 MB 00184/MB/BHP HRSA HHS; AA01455-01-06/AA/NIAAA NIH HHS; HD-2274/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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