Document Detail


Seasonality, malaria, and impact of prophylaxis in a West African village I. Effect of anemia in pregnancy.
MedLine Citation:
PMID:  9158044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The importance of malaria as a cause of anemia in pregnancy in endemic areas remains controversial. The prevalence of anemia in pregnant women following the dry (May) and the rainy (November) seasons was compared in two successive years in Bougoula village (region of Sikasso, Mali). Phase I (1992) was observational and included 172 pregnant women and 208 controls. In Phase II (1993, 174 pregnant women and 206 controls), malaria prophylaxis with proguanil (200 mg/day) and chloroquine (300 mg/week) was offered to pregnant women. A strong seasonal variation in the prevalence of moderate to severe anemia in pregnant women (hematocrit < 30%) occurred in Phase I (dry season = 8.7%, rainy season = 41.2%). This variation was present only in women of parity lower than five, and paralleled variation in parasitemia. In Phase II, the seasonal variation of anemia was suppressed in women under malaria prophylaxis (presence of antimalarial metabolites in urine), and the overall prevalence of moderate to severe anemia in pregnancy decreased by 55.5% (22.8-74.3%). We conclude that malaria is the major cause of anemia in pregnancy in this region. A high priority should be given to prevention of malaria in pregnancy.
Authors:
P Bouvier; O Doumbo; N Breslow; C F Robert; A Mauris; M Picquet; B Kouriba; H K Dembele; V Delley; A Rougemont
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  56     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-02     Completed Date:  1997-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  378-83     Citation Subset:  AIM; IM    
Affiliation:
Institute of Social and Preventive Medicine, University of Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia / epidemiology*,  etiology
Antimalarials / therapeutic use
Censuses
Chloroquine / therapeutic use
Cross-Sectional Studies
Female
Hematocrit
Humans
Intervention Studies
Interviews as Topic
Iron / therapeutic use
Malaria / complications,  epidemiology,  prevention & control*
Mali / epidemiology
Middle Aged
Parity
Pregnancy
Pregnancy Complications, Hematologic / epidemiology*,  etiology
Pregnancy Complications, Parasitic / epidemiology,  prevention & control*
Prevalence
Seasons*
Chemical
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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