Document Detail

Seasonality of birth in epilepsy: a Danish study.
MedLine Citation:
PMID:  9858097     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: A recent British epidemiological study, having found that the seasonality of birth in a large epileptic sample was significantly different from that of the general population, has pointed to neurodevelopmental disruption as the likely mechanism to cause at least part of the epilepsies of unknown aetiology. The aim of this study is to replicate the British study using a large Danish sample. MATERIAL AND METHODS: The population studied is composed by all the 50,886 patients discharged from Danish Hospitals, with a diagnosis of epilepsy, in the period from 1977 to 1993. The seasonal pattern of birth in this sample has been compared, using regression methods, with all the live births in Denmark. RESULTS: The results were strikingly similar to the British study, with a deficit of epileptic births in September and an excess during the winter months. CONCLUSION: This study seems to confirm the seasonal presence in the environment of an aetiological factor(s) for epilepsy which acts in the perinatal period disrupting the neurodevelopment.
M Procopio; P K Marriott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  98     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
The Princess Royal Hospital, Haywards Heath, West Sussex, UK.
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MeSH Terms
Denmark / epidemiology
Epilepsy / epidemiology,  etiology*
Middle Aged
Models, Statistical
Nervous System / growth & development
Poisson Distribution
Prenatal Exposure Delayed Effects*
Risk Factors

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