Document Detail


Seasonal variations of gonadotropins in the pars distalis male viscacha pituitary. Effect of chronic melatonin treatment.
MedLine Citation:
PMID:  16216815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gonadotropes, LH and FSH cells, were immunohistochemically identified in the pituitary pars distalis of the adult male viscacha (Lagostomus maximus maximus) using specific antibodies against hLHbeta and hFSHbeta with the streptavidin-biotin-peroxidase complex. The distribution, size and percentage immunopositive area of these cells were analyzed by image analysis in viscachas captured during the annual reproductive cycle and after the chronic administration of melatonin. The LHbeta and FSHbeta cells showed seasonal changes in the distribution, size and percentage immunopositive area. The LHbeta cells were found widely distributed throughout the pars distalis during the reproductive period, and they were found in the ventro-medial region in the pars distalis during the gonadal regression and gonadal recovery periods. The LHbeta cells reached the largest size and immunopositive area during the reproductive period and the smallest size and immunopositive area during the gonadal regression period. The FSHbeta cells were found in the ventro-medial region during reproductive and gonadal regression periods. The FSHbeta cells were found widely distributed throughout the pars distalis during the gonadal recovery period when they showed the maximum percentage immunopositive area. A decrease in the size of LHbeta and FSHbeta cells was observed after the chronic administration of melatonin. Moreover, it produces a decrease in the immunopositive area occupied by the LHbeta cells but not in the immunopositive area occupied by the FSHbeta cells. Our results show great activity of LHbeta and FSHbeta cells in different moments of the annual reproductive cycle demonstrating that these cells do not secrete in parallel. Moreover, melatonin acts differentially on the activity of the gonadotrope cells.
Authors:
V Filippa; A Penissi; F Mohamed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of histochemistry : EJH     Volume:  49     ISSN:  1121-760X     ISO Abbreviation:  Eur J Histochem     Publication Date:    2005 Jul-Sep
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-01-04     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  9207930     Medline TA:  Eur J Histochem     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  291-300     Citation Subset:  IM    
Affiliation:
Cátedra de Histología y Embriología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina. vpfilipp@unsl.edu.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight
Gonadotropins, Pituitary / analysis,  metabolism*
Immunohistochemistry
Male
Melatonin / pharmacology*
Pituitary Gland, Anterior / drug effects,  physiology*,  ultrastructure
Rodentia / physiology*
Seasons*
Secretory Vesicles / drug effects,  physiology*,  ultrastructure
Time Factors
Chemical
Reg. No./Substance:
0/Gonadotropins, Pituitary; 73-31-4/Melatonin

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