Document Detail

Seasonal variations of clinical and biochemical parameters in chronic haemodialysis.
MedLine Citation:
PMID:  15608835     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Seasonal variations in clinical and laboratory variables occur commonly among chronic haemodialysis patients. In order to demonstrate seasonal differences, we prospectively compared biochemical and clinical parameters in a group of chronically haemodialysed patients living in South Croatia, a region with a Mediterranean climate. MATERIALS AND METHODS: Data were processed on 135 single dialysis treatments involving a group of 34 anuric chronic haemodialysis (HD) patients. Outcomes were measured at 3-month intervals, in March, June, September and December. RESULTS: The seasonal differences were found in phosphorus (P = 0.001), creatinine before HD (P <0.001), creatinine after HD (P = 0.005), alkaline phosphatase (P = 0.012), alanine aminotransferase (P = 0.042), urea before HD (P = 0.039), albumins (P <0.001), total cholesterol (P <0.001), low-density lipoprotein (LDL) cholesterol (P <0.001), high-density lipoprotein (HDL) cholesterol (P <0.001), glucose (P = 0.033), and ultrafiltration per HD (P = 0.037). When the data were grouped into cold (March and December) and mild (June and September) months, we found differences in phosphorus (1.48 +/- 0.47 versus 1.72 +/- 0.51, P = 0.005), alkaline phosphatase (119.46 +/- 69.03 versus 169.78 +/- 107.98, P = 0.002), urea before HD (27.13 +/- 5.35 versus 24.40 +/- 5.99, P = 0.006), albumins (37.92 +/- 5.17 versus 40.58 +/- 5.69, P = 0.006), total cholesterol (4.93 +/- 0.93 versus 5.30 +/- 0.93, P = 0.023), LDL cholesterol (2.85 +/- 1.04 versus 3.23 +/- 0.87, P = 0.046), glucose (4.62 +/- 1.15 versus 5.57 +/- 1.46, P = 0.004), and ultrafiltration per HD (3.57 +/- 1.18 versus 2.97 +/- 1.20, P = 0.004). CONCLUSION: In Mediterranean climates, seasonal differences in predialysis urea concentration and ultrafiltration rate per dialysis could be attributed to different food and water intake. The seasonal differences in blood concentration of phosphorus, alkaline phosphatase, total cholesterol, LDL cholesterol, and glucose might be the results of neurohormonal influences. This climate has no impact on haemoglobin and blood pressure levels.
V Kovacic; V Kovacic
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  33     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-20     Completed Date:  2005-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  763-8     Citation Subset:  IM    
Dr Vedran Kovacic, Ivana Gundulica 3a, 21220 Trogir, Croatia.
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MeSH Terms
Kidney Failure, Chronic / blood*,  therapy
Mediterranean Region
Prospective Studies
Renal Dialysis*

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