Document Detail


Seasonal variation in the response of adipose tissue to a serum fat-mobilizing factor may be explained in terms of reduced availability of fat cell receptors.
MedLine Citation:
PMID:  7319466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lipolytic activity of serum obtained from fasted rats on rat isolated rat cells, exhibits seasonal trends. If it is assumed that the serum lipolytic agonist combines with receptors on fat cell membranes, and that the measured physiological response (glycerol release) is proportional to the number of such combinations, then the observed seasonal variation could be due to changes in serum concentration of lipolytic agonist, or the sensitivity of cells towards the same concentration of agonist (or both). On the basis of the observations described herein, it is proposed that the seasonal fluctuation in fat cell sensitivity is the result of some measure of altered availacbility of receptors for the lipolytic agonist. Possible changes in the concentration of circulating agonist, which were not investigated, may also play a role.
Authors:
P B Curtis-Prior
Related Documents :
1551916 - Cysteine 647 in the insulin receptor is required for normal covalent interaction betwee...
17420586 - Phylogenetic and disruption analyses of aspartate kinase of deinococcus radiodurans.
3525156 - Insulin receptors of chicken liver and brain. characterization of alpha and beta subuni...
2200676 - Structural requirements for signal transduction of the insulin receptor.
17145116 - Role of receptor interaction in the mode of action of insecticidal cry and cyt toxins p...
23495186 - Structure of the olfactory receptor organs, their gabaergic neural pathways, and modula...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  13     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  686-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects,  metabolism*
Animals
Dose-Response Relationship, Drug
Fasting
Glycerol / metabolism
Lipolysis / drug effects*
Male
Peptides / blood,  pharmacology*
Rats
Rats, Inbred Strains
Receptors, Drug / metabolism*
Seasons*
Chemical
Reg. No./Substance:
0/Peptides; 0/Receptors, Drug; 0/lipid mobilizing substance; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recovery of secretin in acid small intestinal lumen perfusates in the rabbit.
Next Document:  Muscle LPL activity, plasma and muscle triglycerides in trained thyroidectomized rats.