Document Detail

Seasonal variation in the response of adipose tissue to a serum fat-mobilizing factor may be explained in terms of reduced availability of fat cell receptors.
MedLine Citation:
PMID:  7319466     Owner:  NLM     Status:  MEDLINE    
The lipolytic activity of serum obtained from fasted rats on rat isolated rat cells, exhibits seasonal trends. If it is assumed that the serum lipolytic agonist combines with receptors on fat cell membranes, and that the measured physiological response (glycerol release) is proportional to the number of such combinations, then the observed seasonal variation could be due to changes in serum concentration of lipolytic agonist, or the sensitivity of cells towards the same concentration of agonist (or both). On the basis of the observations described herein, it is proposed that the seasonal fluctuation in fat cell sensitivity is the result of some measure of altered availacbility of receptors for the lipolytic agonist. Possible changes in the concentration of circulating agonist, which were not investigated, may also play a role.
P B Curtis-Prior
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  13     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  686-8     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / drug effects,  metabolism*
Dose-Response Relationship, Drug
Glycerol / metabolism
Lipolysis / drug effects*
Peptides / blood,  pharmacology*
Rats, Inbred Strains
Receptors, Drug / metabolism*
Reg. No./Substance:
0/Peptides; 0/Receptors, Drug; 0/lipid mobilizing substance; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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