Document Detail

Seasonal variation in the prevalence of Down syndrome at birth: a review.
MedLine Citation:
PMID:  9328537     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Many studies on seasonality in Down syndrome (DS) have been performed and have come to different conclusions. It is suggested that seasonal variation in hormone production by the hypothalamus-pituitary-ovarian axis just before ovulation leads to seasonality in conception rates of DS. This study aimed to determine whether there is seasonal variation in the prevalence of DS at birth as a proxy for seasonality in DS at conception. DESIGN: All the English and Dutch articles on this topic were reviewed. Articles published between 1966 and January 1996 were traced by Medline, and by the reference lists. MAIN RESULTS: Twenty articles met the criteria for inclusion. Although seven of these studies reported seasonality in DS prevalence, no consistent seasonal pattern was found in DS at birth in these studies, or in the remaining studies. A seasonal pattern could not have been masked by the effects of maternal age, induced abortions, shortened gestation, or misclassification of DS. CONCLUSION: Seasonality in the prevalence of DS at birth does not exist. Evidence did not support the suggestion that DS occurrence is related to seasonality in hormone production.
A M Stolwijk; P H Jongbloet; G A Zielhuis; F J Gabreëls
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of epidemiology and community health     Volume:  51     ISSN:  0143-005X     ISO Abbreviation:  J Epidemiol Community Health     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-29     Completed Date:  1997-10-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7909766     Medline TA:  J Epidemiol Community Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  350-3     Citation Subset:  IM    
Department of Medical Informatics, Epidemiology and Statistics, University of Nijmegen, The Netherlands.
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MeSH Terms
Down Syndrome / epidemiology*
England / epidemiology
Hormones / biosynthesis
Infant, Newborn
Netherlands / epidemiology
Reg. No./Substance:

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