Document Detail


Seasonal variation in the incidence of congenital hypothyroidism in Isfahan, Iran.
MedLine Citation:
PMID:  17914523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the seasonal variations in the incidence of congenital hypothyroidism (CH) in the screening program of CH in Isfahan, Iran. METHODS: In this study, we compiled the data obtained retrospectively from CH screening results of 113282 neonates from 17 maternity hospitals in Isfahan, Iran from June 2002 to December 2005. The seasonal variation in the incidence of CH, as well as its monthly incidence was analyzed using all the diagnosed cases of CH. RESULTS: From the 113282 neonates referred for CH screening, 358 neonates were diagnosed with CH, showing an overall incidence of 3.1/1000 live birth. There was no significant difference in the seasonal variation of CH (p=0.5). According to the monthly distribution analysis, the incidence of CH was higher in the second month of summer (Mordad) and lower in the last month of autumn (Azar)(p=0.04). CONCLUSION: The high incidence of CH in Mordad, the second month of summer, supports the hypothesis that certain environmental factors such as intrauterine viral infections (which commonly exhibit seasonal variations in incidence), exposure to chemical compounds, differences in climate and so forth, may play a role in the etiology of this disorder. Awareness of the monthly distribution of CH incidence could help us identify associated environmental factors and aid in the development of preventative strategies. Further, it would for the appropriate allocation of resources within the screening programs.
Authors:
Mahin Hashemipour; Massoud Amini; Roya Kelishadi; Silva Hovsepian; Sassan Haghighi; Mohsen Hosseini; Mojtaba Talaei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Saudi medical journal     Volume:  28     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-02-27     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1582-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Isfahan Endocrine & Metabolism Research Center, Isfahan University of Medical Sciences & Health Services, Sedigheh Tahereh Research Center, Jomhouri Square, Isfahan, Iran. hashemipour@med.mui.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Congenital Hypothyroidism / epidemiology*
Humans
Incidence
Infant, Newborn
Iran / epidemiology
Seasons*

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